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Review Article Open Access
Volume 1 | Issue 1 | DOI: https://doi.org/10.46439/signaling.1.006

Approach to testicular adrenal rest tumors in children and adolescents with congenital adrenal hyperplasia

  • 1Department of Pediatric Endocrinology, School of Medicine, Ankara University, Ankara, Turkey
+ Affiliations - Affiliations

Corresponding Author

Sirmen Kizilcan Cetin, drsrmnkzlcn@gmail.com

Received Date: March 26, 2023

Accepted Date: May 24, 2023

Abstract

Testicular adrenal rest tumor (TART) is a long-standing, significant complication of congenital adrenal hyperplasia (CAH). Although it is the main reason for infertility in adult patients with CAH, little is known about the development mechanism, genotype-phenotype features, and exact treatment options of TART. However, in the literature, there are mainly case reports and only a few studies in the pediatric period on this subject. The critical point is the early detection of tumors to prevent infertility in adulthood. This paper 
reviews the embryological, clinical, diagnostic, genetic features, and treatment alternative of TART and discusses the early screening options.

Keywords

Testicular adrenal rest tumor, TART, Congenital adrenal hyperplasia, Infertility, Genotype-phenotype correlation

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