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Cell Signaling
ISSN: 2837-8253
2025
Volume 3, Issue 1, p1-89
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
PDE4 inhibition and enhancement of human memory and cognition
Graeme B. Bolger
Two distinct, but intertwining, threads of inquiry have demonstrated that the PDE4, or cAMP-selective, phosphodiesterases, have an essential role in human cognition, learning and memory. Study of genetically-modified preclinical models, and of humans with mutations in the PDE4D gene, has provided some of the most rigorous proof of the importance of PDE4 signaling in the CNS. More recently, clinical trials of PDE4-selective inhibitors have shown promising clinical activity in disorders of cognition and memory.
Cell Signal, 2025, Volume 3, Issue 1, p1-9 | DOI: 10.46439/signaling.3.048
The extract of Nicotiana glauca induces apoptosis in rhabdomyosarcoma cells
Lucía Pronsato, Lorena Milanesi, Andrea Vasconsuelo, Natalia Frattini, Nicolás Blanco
Cancer is a leading cause of childhood mortality, with rhabdomyosarcoma (RMS) being the most prevalent type diagnosed in approximately two-thirds of pediatric cancer cases, particularly the embryonal subtype. RMS represents the most common soft tissue sarcoma in children and adolescents, accounting for around 2-3.5% of all pediatric malignancies [1].
Cell Signal, 2025, Volume 3, Issue 1, p10-18 | DOI: 10.46439/signaling.3.049
Cognitive impairment in hemodialysis needs sufficient attention
Jun Liu, Yani He, Kehong Chen
Hemodialysis is the most common form of kidney replacement worldwide. It is expected that the acceptance rate of hemodialysis will continue to increase in the coming decades [1]. About 89% of dialysis patients worldwide receive hemodialysis. The majority of these patients are living in high-income countries or middle to high-income countries such as Brazil and South Africa.
Cell Signal, 2025, Volume 3, Issue 1, p19-22 | DOI: 10.46439/signaling.3.050
Recombinant protein synthesis and isolation of human interferon alpha-2 in cyanobacteria
Anastasios Melis, Bharat Kumar Majhi
Interferons (IFNs) are a class of small immunological proteins that are secreted by infected cells during viral or bacterial infections to combat and prevent infection propagation [1]. They play important roles in triggering signal cascade processes inside the cell that activate other immune cells and limit viral multiplication.
Cell Signal, 2025, Volume 3, Issue 1, p23-26 | DOI: 10.46439/signaling.3.051
Insights into early acne pathogenesis: Exploring intercellular dynamics and key dysregulated genes
Min Deng, Kiana Farahani, George W. Agak
Acne vulgaris, the most common skin condition worldwide, affects over 85% of adolescents, with nearly half continuing to experience it into adulthood. The Scarring and post-inflammatory hyperpigmentation associated with acne can profoundly impact mental health and self-esteem, underscoring the importance of early and effective treatment [1].
Cell Signal, 2025, Volume 3, Issue 1, p32-39 | DOI: 10.46439/signaling.3.053
Comment on “Hsa_Circ_0105596/FTO inhibits progression of Parkinson’s disease by sponging miR-187-3p and regulating eEF2”
Taoli Liu, Shumin Cheng, Qingqing Zhu
Parkinson’s disease (PD), a progressive neurodegenerative disorder, characterized by clinical features such as bradykinesia and resting tremor. It is characterized by specific neuropathological changes. These changes include the degeneration of dopaminergic neurons in the substantia nigra (SN) pars compacta.
Cell Signal, 2025, Volume 3, Issue 1, p40-41 | DOI: 10.46439/signaling.3.054
The role of stress granules in heavy metal-induced carcinogenesis
Rukayat Aromokeye, Megan Carver, Haining Zhu, Lei Wang
Stress granules (SGs) are dynamic, membraneless organelles that assemble in response to cellular stress, such as oxidative stress, hypoxia, or nutrient deprivation [1,2]. Protein translation typically is halted under stress conditions, leading to assembly of SGs containing mRNAs, RNA-binding proteins (RBPs), and other proteins.
Cell Signal, 2025, Volume 3, Issue 1, p43-46 | DOI: 10.46439/signaling.3.055
The role of circulating anti-aging αKlotho in cardiac aging
Dong I Lee, Dao-Fu Dai
Aging is an inevitable biological process that significantly affects various organs, including the heart. Cardiac aging, with its associated structural and functional changes, can lead to left ventricular (LV) hypertrophy, diastolic dysfunction, increased arterial stiffness, and reduced overall cardiac functional reserve [1,2].
Cell Signal, 2025, Volume 3, Issue 1, p54-58 | DOI: 10.46439/signaling.3.057
The combination of TSPO ligands and CDK1 inhibitors may be a novel approach for the treatment of malignant peripheral nerve sheath tumor
Xingnan Zhang, Song Liu
MPNSTs are aggressive Schwann cell-derived sarcomas, frequently associated with NF1 mutations. Traditional treatments, including surgery and chemotherapy, are largely ineffective, highlighting the urgent need for novel therapeutic strategies. NF1 loss leads to RAS pathway activation, which in turn activates multiple signaling cascades, including RAF-MEK-ERK1/2, PI3K-AKT, and RalGDS pathways. Inhibition of these pathways has been explored, with MEK inhibitors, such as selumetinib, showing some promise in clinical trials (NCT03433183).
Cell Signal, 2025, Volume 3, Issue 1, p59-63 | DOI: 10.46439/signaling.3.058
Sirt1-mediated deacetylation in MAFLD: Mechanisms and therapeutic implications
Libang Chen, Qian Lu, Tingting Yang
Apart from alcohol and other definitive factors, metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a clinicalpathological syndrome characterized by hepatic steatosis and lipid accumulation.
Cell Signal, 2025, Volume 3, Issue 1, p69-75 | DOI: 10.46439/signaling.3.060
A new role of dopamine receptor D2 agonist ropinirole: Targeting NAT10 for treating periodontitis
Jiahui Tan, Jialei Wu, Lufei Wang
Periodontitis is a chronic inflammatory disease that affects more than 40% of the adult population aged over 30 years in the United States, indicating a high prevalence [1]. It impairs the integrity of the tooth-supporting tissue with clinical manifestations featured of gingiva bleeding, periodontal ligament degradation, and alveolar bone resorption. Periodontitis is a multifactorial disease, involving interactions of bacterial pathogens, host immune responses and environmental factors such as smoking [2].
Cell Signal, 2025, Volume 3, Issue 1, p76-79 | DOI: 10.46439/signaling.3.061
Complex actions of amyloid beta on hippocampal neurogenesis in Alzheimer’s disease pathogenesis
Jaehoon Song, Inhee Mook-Jung
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory impairment. One of the key pathological hallmarks of AD is the accumulation of amyloid beta (Aβ), a peptide derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases .
Cell Signal, 2025, Volume 3, Issue 1, p80-84 | DOI: 10.46439/signaling.3.062
Engineered Ag135Cu60 nanoclusters with buckminsterfullerene topology: Structure and optical dynamics
QiKai Han, Li Tang, Shuxin Wang
Metal nanoclusters, serving as a mesoscopic bridge between discrete atoms and bulk materials, have emerged as a frontier in the convergence of coordination chemistry and material science.
Cell Signal, 2025, Volume 3, Issue 1, p85-89 | DOI: 10.46439/signaling.3.063
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