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Cell Signaling
ISSN: 2837-8253
2026
Volume 4, Issue 1, p10-36
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Cellular conversations at the crossroads of health and disease
Anne-Sophie Armand, Patrice X. Petit
The first issue of Cell Signaling in 2025 provides an interdisciplinary overview of cellular communication, covering topics ranging from neuronal and metabolic regulation to immune evolution and regenerative processes. The studies featured in this volume collectively demonstrate how signaling pathways govern the delicate, finely tuned balance between adaptation and dysfunction, and how their manipulation continues to inspire biotechnological and therapeutic innovation.
Cell Signal, 2026, Volume 4, Issue 1, p10-13 | DOI: 10.46439/signaling.4.088
Effects of salt on A2A adenosine receptors expression and function: in vitro approach and pathophysiological perspectives
Farid El Oufir, Aboubacar Sow, Claire Guiol, Marion Marlinge, Aissatou Pethwol Bah, Nathalie Kipson, Christine Criado, Marie-Charlotte Chaptal, Simon Lledo, Julia Dodivers, Julien Fromonot, Jean Ruf, Régis Guieu, Giovanna Mottola
Salt (sodium chloride) and A2A adenosine receptors (A2AR) have both been implicated in blood pressure regulation. While high salt consumption raises blood pressure, A2AR is a key mediator of coronary vasodilation. Although a sodium ion binding pocket has been identified in A2AR, the physiological link between salt and A2AR remains poorly investigated. Hereby, we explored how salt modulates its expression and function in vitro.
Cell Signal, 2026, Volume 4, Issue 1, p14-20 | DOI: 10.46439/signaling.4.089
Emerging hallmarks of GEMIN5 in neurodevelopmental disease
Encarnacion Martinez-Salas, PhD, Salvador Abellan, Rosario Francisco-Velilla
GEMIN5 is a modular RNA-binding protein responsible for the recognition of snRNAs through its WD40 domain placed at the N-terminus. A dimerization module at the central region of the protein acts as a hub for protein-protein interaction, and a non-canonical RNA-binding domain is placed towards the C-terminus. Recent studies reported loss of function Gemin5 biallelic variants which develop cerebellar ataxia, hypotonia and neurodevelopmental delay, indicating that GEMIN5 deficiency is detrimental for survival.
Cell Signal, 2026, Volume 4, Issue 1, p21-24 | DOI: 10.46439/signaling.4.090
Current advances and future directions in cell signaling: redox communication and emerging therapeutic paradigms
Andrea Albieri-Borges
Cell signaling represents a highly coordinated molecular dialogue that governs cellular behavior and tissue homeostasis. Among its many facets, redox signaling has emerged as a pivotal mechanism, transforming our understanding of reactive oxygen species (ROS) from mere metabolic byproducts to essential messengers [1]. Historically associated with oxidative stress and cellular damage, ROS are now recognized as regulators of physiological processes through reversible oxidation of cysteine residues in proteins.
Cell Signal, 2026, Volume 4, Issue 1, p25-27 | DOI: 10.46439/signaling.4.091
NUB1 protein localization as a prognostic modifier in ER-negative breast cancer
Ka-Liong Tan, Francesco Pezzella
Breast cancer remains a heterogeneous disease in which prognostic stratification, particularly within estrogen receptor (ER)-negative subtypes, remains clinically challenging. While genomic and transcriptomic profiling have advanced risk classification, protein-level regulation and subcellular localization are rarely incorporated into prognostic frameworks. NEDD8 ultimate buster 1 (NUB1) is a proteostasis-associated protein involved in degradation of ubiquitin-like modifiers and regulation of cell-cycle progression.
Cell Signal, 2026, Volume 4, Issue 1, p28-30 | DOI: 10.46439/signaling.4.092
Development of an error-corrected next-generation sequencing method for the quantification of hotspot cancer driver mutations
Kelly L. Harris
Low-frequency somatic mutations accumulate in normal tissues throughout life and contribute to cancer initiation, yet their detection is limited by the sensitivity of conventional sequencing methods. We describe CarcSeq, an error-corrected, targeted next-generation sequencing platform developed to quantify rare cancer driver mutations (CDMs) at variant allele frequencies as low as ~10-4. CarcSeq integrates high-fidelity amplification, unique molecular identifiers, and single-strand consensus sequencing to accurately measure mutant frequency (MF) across a curated panel of sequences encompassing recurrent oncogene and tumor suppressor hotspots.
Cell Signal, 2026, Volume 4, Issue 1, p31-36 | DOI: 10.46439/signaling.4.093
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