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Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/signaling.3.074

Chemokine-like Orion presentation as a potential switch in phagocytic signaling pathway activation during neuronal remodeling

  • 1IGH, Univ Montpellier, CNRS, Montpellier, France
  • 2Institute of Functional Genomics (IGF), University of Montpellier, CNRS, INSERM, Montpellier, France
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Corresponding Author

Jean-Maurice Dura, jean-maurice.dura@igh.cnrs.fr ; Ana Boulanger, ana.boulanger@igf.cnrs.fr

Received Date: July 28, 2025

Accepted Date: September 02, 2025

Abstract

Immature nervous systems are initially overpopulated with neurons. A crucial step of remodeling that removes inappropriate connections is required and performed predominantly by phagocytic glial cells. The Drosophila chemokine-like Orion tags axons to be eliminated. Could the way Orion is presented by neurons be the critical factor in modulating subsequent intracellular glial responses? Here we propose a model in which the mode of Orion presentation (soluble, GAG-bound, PS-bound, or EV-associated) might function as a switch in phagocytic signaling during neural remodeling.

Keywords

Chemokine-like Orion, Neuron, Glia, Infiltration, Phagocytosis, Neuronal remodeling

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