Abstract
Immature nervous systems are initially overpopulated with neurons. A crucial step of remodeling that removes inappropriate connections is required and performed predominantly by phagocytic glial cells. The Drosophila chemokine-like Orion tags axons to be eliminated. Could the way Orion is presented by neurons be the critical factor in modulating subsequent intracellular glial responses? Here we propose a model in which the mode of Orion presentation (soluble, GAG-bound, PS-bound, or EV-associated) might function as a switch in phagocytic signaling during neural remodeling.
Keywords
Chemokine-like Orion, Neuron, Glia, Infiltration, Phagocytosis, Neuronal remodeling