Abstract
An investigation of comprehensive changes and shared dysregulated signaling pathways across acne patients in the early stages remains largely unexplored. In our recently published paper entitled “Analysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin,” we utilized single-cell RNA sequencing and spatial RNA-seq datasets from acne patients to analyze cell communication. We identified dysregulated genes associated with inflammatory responses and hyperkeratinization. This commentary discusses new potential markers in major skin cell types, including endothelial cells, fibroblasts, lymphocytes, myeloid cells, keratinocytes, and smooth muscle cells. We also discuss key dysregulated genes associated with inflammation and hyperkeratinization in acne lesions, focusing on the intricate interplay between these processes. Based on our findings, we discussed potential FDA-approved treatments targeting two key pathways involved in acne pathogenesis. These insights offer new therapeutic targets for acne treatment.
Keywords
Acne vulgaris, Cell-cell interaction, Early-stage of acne, Cell markers in the skin, Inflammatory response, TREM2 macrophages, GRN-SORT1, Hyperkeratinization, Keratinocyte, IL-13-IL13-RA1