Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/signaling.3.068
NCAM1: A newly discovered immune checkpoint in molluscs and its functions in immune regulation
Muchun He1,3, Renle Chang1,3,†, Jiejie Sun1,3,*, Linsheng Song1,2,3,*
- 1Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University, Dalian 116023, China
- 2Laboratory of Marine Fisheries Science and Food Production Process, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266235, China
- 3Dalian Key Laboratory of Aquatic Animal Disease Prevention and Control, Dalian Ocean University, Dalian 116023, China
- †These authors contributed equally to this work
Corresponding Author
Jiejie Sun, sunjiejie@dlou.edu.cn, Linsheng Song, lshsong@dlou.edu.cn
Received Date: April 03, 2025
Accepted Date: April 21, 2025
He M, Chang R, Sun J, Song L. NCAM1: A newly discovered immune checkpoint in molluscs and its functions in immune regulation. Cell Signal. 2025;3(1):111-114.
Copyright: © 2025 He M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
Drosophila male germline stem cells and their transit amplifying daughters depend on G-protein signaling for increasing their mitotic indices in response to mating
In many metazoan tissues, highly specialized cells are constantly lost and need to be replaced by tissue homeostasis from adult stem cells. When adult stem cells divide by mitosis their daughter cells either become new stem cells, or enter a proliferation and differentiation path. Recent studies in Drosophila males showed that germline stem cells (GSCs) can increase their mitotic activity in response to repeated mating.
Drought treatment: A new tool for dissecting XA21 signaling in rice
Microbial infection can cause cell damage in both plants and animals, as well as triggering stress responses commonly induced by environmental (abiotic) cues.
Involvement of TGFβ signaling pathway in oxidative stress and diabetic retinopathy
Diabetic Retinopathy (DR) is a leading cause of blindness in the U.S. However, not much is known of underlying molecular mechanism and how oxidative stress contributes to its development. In the present study, we investigated the involvement of TGFβ signaling pathway on the effect of oxidative stress on VEGF secretion and viability of retinal cells. VEGF is the hallmark that exacerbates DR progression in prolonged diabetes. Some major concerns that have arisen are the underlying effects of antioxidants in elevating VEGF secretion in diabetes.
DNA hyper methylation editing of T cell receptor signaling and the fellow molecules: a promise strategy of predicting acquired immune checkpoint inhibitors (ICIs) resistance
The promising results of immune checkpoint inhibitors (ICIs) in tumors have changed the current treatment modality for cancer. ICIs response prediction is urgently needed for the personalized therapy approach. In the recent issue of the Journal of Oncology, Zixin Hu et al. proposed that DNA methylation alternations contribute to tumor microenvironment (TME) reshapement to predict the ICIs response. Notwithstanding the global DNA methylation loss, the repression of T cell receptor signaling and the fellow costimulators by DNA hypermethylation contributed to the cold TME and ICIs resistance.
Perspective study of UPR signaling molecules as potential biomarkers in bone metabolism
The skeletal system consists mostly of extracellular matrix and mineral salts. Osteoblasts and chondrocytes create enormous amounts of extracellular matrix proteins for skeletal systems to grow and sustain. Many skeletal metabolism related proteins are produced by endoplasmic reticulum (ER) and secrete outside cell membrane then form to extracellular oligometric matrix proteins and collagens.