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Cell Signaling

ISSN: 2837-8253

Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/signaling.3.055

The role of stress granules in heavy metal-induced carcinogenesis

Rukayat Aromokeye1, Megan Carver1, Haining Zhu1,2,3,*, Lei Wang1,*
  • 1Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA
  • 2Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA
  • 3Research Service, Department of Veteran Affairs Southern Arizona Health Care, Tucson, AZ, USA
+ Affiliations - Affiliations

Corresponding Author

Haining Zhu, haining@arizona.edu;
Lei Wang, leiw1@arizona.edu

Received Date: December 13, 2024

Accepted Date: January 06, 2025

Citation:

Aromokeye R, Carver M, Zhu H, Wang L. The role of stress granules in heavy metal-induced carcinogenesis. Cell Signal. 2025;3(1):43-46.


Copyright: © 2025 Aromokeye R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In our recent published study entitled “Stress granules play a critical role in hexavalent chromium-induced malignancy in a G3BP1-dependent manner”, we explored how hexavalent chromium [Cr(VI)] exposure induces stress granule (SG) formation in human bronchial epithelial cells and how SGs contribute to the malignancy. We found that the loss of the SG core protein Ras-GAP SH3 domain-binding protein 1 (G3BP1) reduced SG formation and malignant properties. The results support that SGs play a critical role in mediating Cr(VI)-induced malignancy in a G3BP1-dependent manner, representing a novel mechanism and a potential therapeutic target. In this commentary, we introduce more in-depth background, summarize key findings of the published work, present additional data addressing a related question, and discuss emerging questions and future research directions.

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