Loading

logo

Cell Signaling

ISSN: 2837-8253

Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/signaling.3.076

Angiotensin-(1-7) steers macrophages to inflammation resolution

Simone de Araújo1,#,*, Erick Bryan de Sousa Lima2,3,#, Lirlândia P. Sousa3, Mauro Martins Teixeira4
  • 1Animal Experimentation Center, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
  • 2Postgraduate Program in Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil
  • 3Signaling in Inflammation Laboratory, Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil
  • 4Department of Biochemistry and Immunology, Institute of Biological Sciences and Center for Advanced and Innovative Therapies, Federal University of Minas Gerais, Belo Horizonte, Brazil
  • #These authors contributed equally to this work: Lirlândia P. Sousa and Mauro M. Teixeira co-senior authors.
+ Affiliations - Affiliations

Corresponding Author

Simone de Araújo, simonearaujo@ufmg.br

Received Date: September 08, 2025

Accepted Date: September 19, 2025

Citation:

de Araújo S, de Sousa Lima EB, Sousa LP, Teixeira MM. Angiotensin-(1-7) steers macrophages to inflammation resolution. Cell Signal. 2025;3(1):147-152.


Copyright: © 2025 de Araújo S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Angiotensin-(1-7) [Ang-(1-7)] is a biologically active peptide of the renin–angiotensin system (RAS) that counterbalances the actions of angiotensin II (Ang II), primarily through binding to the Mas receptor (MasR). This axis exerts significant immunomodulatory effects by influencing several features of leukocytes, including macrophage function, a central component in the resolution of inflammation. Macrophages contribute to tissue homeostasis by clearing apoptotic cells, releasing anti-inflammatory mediators and supporting tissue repair. Herein, we highlight the evidence supporting the role of Ang-(1-7) in guiding macrophages toward inflammation resolution. In this context, Ang-(1-7)/MasR signaling has been shown to induce several functions in macrophages, including suppression of pro-inflammatory activity, enhancement of apoptotic cells efferocytosis and bacterial phagocytosis, and promotion of macrophage polarization toward regulatory phenotypes.

Keywords

Macrophages, Mas receptor (MasR), Ang-(1-7), Inflammation resolution, Efferocytosis

Recommended Articles

Neodymium:YAG laser posterior capsulotomy in the lateral decubitus position

Here we report a novel method of performing a Neodyminium:YAG (Nd:YAG) laser posterior capsulotomy in an adult patient, unable to tolerate the procedure awake with topical anaesthesia in the outpatient clinic setting. The procedure was performed by altering the chin rest and arms of the Nd:YAG laser machine so that the procedure could be undertaken in an anaesthetized patient in the operating theatre, in the lateral decubitus position, with the laser machine upright in its normal position.

Presbyopia correcting IOLs and the ocular surface disease… The good, the bad and the ugly

The last two decades were especially fruitful for the refractive surgeons and for the industry who have been showing tremendous development in both understanding and meeting patients’ desire for spectacle independence. Ever since the first trials from Dr. Kenneth Hoffer with his early 1980’s effort in producing a multifocal IOL to the latest achievements from different companies in putting trifocals and EDOF optics to the market.

How many mutations does it take to make a uveal melanoma?

Uveal melanoma (UM) is a rare cancer that affects the choroid and, less frequently, the ciliary body or the iris (for recent reviews see [1-3]). Despite a profound knowledge of the oncogenic mechanisms behind UM tumorigenesis and despite an accurate cytogenetic and molecular prognosis, only limited advances have been made in UM therapy.

MSICS is a Simple Solution for a Big Problem

Manual small-incision cataract surgery (MSICS) is a sutureless cataract surgery that has multiple advantages over traditional phacoemulsification and extracapsular cataract extraction (ECCE) procedures. SICS became the procedure of choice for international ophthalmology, where the microscopes and operating room can be more challenging, in addition to the more advanced pathology often seen.

Surgical smoke and SARS-CoV-2 transmission

The protection of health care workers from nosocomial infection is a paramount consideration in the current pandemic involving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Not only is prevention of viral transmission the most effective means to lessen the public health impact of coronavirus disease 2019 (COVID-19), but also both quarantine and illness – that disproportionately affect health care workers – have devastating effects on the ability of hospitals to adequately care for increased patient loads.

Full Text
Cite
Download PDF
Author Information X