In this case report we present an unusual case of orbital cholesterol granuloma associated with compressive optic neuropathy and cranial nerve 6th palsy. Cholesterol granuloma results from a foreign body response to the presence of crystallized cholesterol. Cholesterol granuloma affecting the orbit are a rare presentation as they typically occur in the petrous apex of the temporal bone.

Partial ureteral obstruction (PUO) is a major clinical problem in the daily urologic practice that is treatable and often reversible. Renin-angiotensin system (RAS) is implicated in the pathophysiology of PUO as angiotensin II induces alterations in renal hemodynamics, apoptosis, inflammation and fibrosis. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) have been clinically used to recover the unfavorable functional and histological changes after relief of PUO.

Chemotherapy remains a cornerstone of modern cancer treatment, yet its neurotoxic side effects can pose significant challenges. Peripheral nerve damage and the resulting pain not only affect patients’ quality of life but also contribute to substantial economic burden.

We report a case of a 51-year-old male presented to the neurology clinic with intermittent dizziness, blurred vision, chronic left sided weakness and numbness. Further workup by brain MRI unearthed increased intracranial pressure secondary to impaired CSF drainage. He was previously diagnosed with Arnold Chiari type I malformation for which ventricle-peritoneal shunt (VPS) was performed in 1994 (Figure 1). Following this, ensuing imaging or evaluation for shunt revision was never attempted.