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Commentary Open Access
Volume 3 | Issue 2 | DOI: https://doi.org/10.46439/neurobiology.3.015

Commentary on Adrenarche and Middle Childhood

  • 1Associate Professor, Department of Anthropology, University of Wisconsin- Milwaukee, Milwaukee, WI 53201, United States
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Corresponding Author

Benjamin Campbell, campbelb@uwm.edu

Received Date: April 05, 2021

Accepted Date: May 06, 2021

Abstract

Adrenarche, the post-natal onset of adrenal production of DHEA (dehydroepiandrosterone) and its sulfate (DHEA-S) marks the 5-8 transition and the onset of middle childhood. However, the role of DHEA and/or DHEA-S in the cognitive, emotional and physical changes of the so-called 5-8 transition are not well-understood. Recent findings from the U.S. NIH Normal Brain and Development Study clearly demonstrate a role for DHEA in the development of the dorsolateral prefrontal cortex, associated with executive function, and the right temporal parietal junction, associated with mentalization. In addition, results from the Australian Childhood to Adolescence Transition study implicate DHEA in increased anxiety during middle childhood through increased connectivity of the amygdala with the anterior cingulate cortex and insula, a circuit that underlies both bodily perception and emotion. At the cellular level, DHEA acts on the sigma-1 receptor to promote both glutamatergic transmission and the production of BDNF (brain derived neurotrophic factor), which in turn promotes activity-dependent synaptic plasticity. The cerebellum has a high portion of glutamatergic neurons, hence DHEA may play a specific role in its development, including the promotion of cerebellar-cortico and cerebellar-limbic connectivity. Furthermore, such circuits have recently been implicated in the development of sensorimotor, cognitive and default mode systems during the 5-8 transition. Taken together these different lines of research suggest that adrenarche plays a key role in brain development and the changes in cognition, behavior and emotion that define the 5-8 transition and middle childhood. Research specifically considering the impact of DHEA on the development of the cerebellum in humans is called for.

Keywords

Adrenarche, DHEA, Middle childhood, Cerebellum, Glutamate

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