Influenza infection remains a serious health problem throughout the world. Unfortunately, current medicine offers no real treatment or protection, moving our attention to alternative options. In this study we aimed to evaluate the possible effects of a combination of glucan and vitamin C on immunosuppression caused by influenza infection.

Systemic lupus erythematosus (SLE) is a relatively common autoimmune disease characterized by the presence of autoantibodies against nucleic acids and proteins that associate with them, such as the ORF1p protein encoded by the long interspersed element-1 (LINE-1 or L1). Because well-known lupus autoantigens like RO60 associate with ORF1p in macromolecular assemblies, together with many other RNA-binding proteins, we tested whether these other proteins are also recognized by IgG autoantibodies in SLE patients. By ELISAs and immunoblots, we detected autoantibodies in the serum of SLE patients recognizing proteins encoded by LARP7, MOV10, ZCCHC3, MEPCE, YARS2, RPL18A, RPL27A, and H2BC17 (p<0.05), but not CORO1B, DDX6, PABPC1, and PABPC4, and were mostly absent or low in healthy controls.

For more than a decade, the nuclear factor kappa-B (NFκB) family and their signaling pathways have proved crucial to the immune system's functioning. According to research, this factor is implicated in almost every immune system event, including immune cell development and function, activation, and pathogen-activated cell death. A considerable body of evidence suggests the idea that, in addition to being a possible transcription factor, it plays a very significant role in the establishment of inflammation-associated immunological responses in host cells. Inflammation is a cascade of events that involve vasodilation and immune cell migration to the site of infection in order to defend the host. 

The major message of this manuscript is that miR-93-5p is a potential therapeutic target in sepsis through the regulation of both innate and adaptive immunity, with possibly a greater benefit for elderly patients than for young patients.

As presented in our previous article, the human immune system is built upon a genetic framework passed down through countless generations. Traditional dietary habits rooted in specific ethnicities have fostered profound immune diversity, enabling adaptation to harsh environmental conditions and ultimately ensuring survival. Consequently, it’s evident that each individual’s immune characteristics are uniquely shaped by a combination of racial background, environmental exposure, and dietary practices.