A man in his 90s presented to clinic with a conjunctival lesion on the right eye noticed two months prior. The patient denied pain but endorsed worsening blurry vision. The patient’s past medical history was significant for skin cancer on the right ear removed 3 years ago, and a history of ocular surface lesion removal on one eye approximately 20 years ago that was negative for any neoplasia. Slit lamp photograph revealed a gelatinous and opalescent lesion suspicious for ocular surface squamous neoplasia (OSSN) and the high-resolution optical coherence tomography (HROCT) cut (arrow)

Sports and exercise medicine (SEM) has undergone significant transformations over the past few decades, mirroring advancements in science, technology, and a growing understanding of the critical role that physical activity plays in overall health and wellbeing. As a multidisciplinary field, SEM encompasses the prevention, diagnosis, treatment, and rehabilitation of injuries and medical conditions related to sports and exercise. It also includes the promotion of physical activity for health benefits. This editorial explores the current trends, challenges, and future directions in SEM, emphasizing the importance of innovation and integration.

Mesenchymal stem cells (MSCs) are widely used in regenerative medicine. They can be isolated from different adult tissues. However, the regenerative potential of MSCs obtained from various sources and from different age donors may significantly differ.

While opioids remain our most potent analgesics in the management of pain, the many potential harms of prescription opioids have become increasingly clear. Despite the analgesic benefits for people with acute and chronic pain [1], opioid therapy (especially long-term opioid treatment) can result in significant problems such as opioid misuse, the development of opioid use disorder, and overdose. Some authors report that up to 20-30% of patients in primary and tertiary care settings who are maintained on long-term opioid therapy misuse opioids (i.e., use them in a manner other than how the opioids are prescribed) [2,3]. Misuse of opioids can cause or exacerbate additional health problems in people with chronic pain [1,4], and in fact, roughly 10% of patients prescribed long-term opioid therapy may develop an opioid use disorder (OUD), although prevalence varies between studies depending on differences in methodology and operational definitions [3]. 

Stem cell therapy for the treatment of cerebral palsy is a rapidly expanding area of research that has been identified as a high priority by consumers. There are several types and sources of stem cell therapies under investigation. Stem cell treatments proposed for cerebral palsy are believed to provide benefit via some or all of the following mechanisms including immunomodulation, paracrine signaling and supporting endogenous reparative processes.