Abstract
Helminths exert systemic immunomodulatory effects characterized by a deviation to a Th2 pattern cytokines. The potential detrimental influence of preexisting helminths infections on COVID-19 by the Th2-like cytokine response is a concern in helminths endemic areas. However, there is also the assumption that preexisting helminth infections may be beneficial by reducing the uncontrolled Th1 pro-inflammatory cytokine response and disease severity. Recent studies show the association between chronic helminth infections and COVID-19 outcome. However, the findings are controversial and potential beneficial and detrimental effects of helminth co-infections on the disease have been reported. More large-scale epidemiological studies are required to reveal the interactions between parasitic infections and COVID-19 and to clarify existing uncertainties. Herein, the current knowledge on the relationship of helminths and SARS-CoV-2 infection is discussed.
Keywords
COVID-19, SARS-CoV-2, Helminths, Co-infection, Th2 response, Immunomodulation.