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Commentary Open Access
Volume 5 | Issue 1 | DOI: https://doi.org/10.46439/allergy.5.043

Effects of helminth co-infections on COVID-19 outcome

  • 1Instituto de Investigaciones Clinicas, Universidad del Zulia, Apartado Postal 23, Maracaibo 4001-A, Venezuela
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Corresponding Author

Leonor Chacín-Bonilla, leonorbonilla42@yahoo.com

Received Date: March 14, 2024

Accepted Date: May 02, 2024

Abstract

Helminths exert systemic immunomodulatory effects characterized by a deviation to a Th2 pattern cytokines. The potential detrimental influence of preexisting helminths infections on COVID-19 by the Th2-like cytokine response is a concern in helminths endemic areas. However, there is also the assumption that preexisting helminth infections may be beneficial by reducing the uncontrolled Th1 pro-inflammatory cytokine response and disease severity. Recent studies show the association between chronic helminth infections and COVID-19 outcome. However, the findings are controversial and potential beneficial and detrimental effects of helminth co-infections on the disease have been reported. More large-scale epidemiological studies are required to reveal the interactions between parasitic infections and COVID-19 and to clarify existing uncertainties. Herein, the current knowledge on the relationship of helminths and SARS-CoV-2 infection is discussed.

Keywords

COVID-19, SARS-CoV-2, Helminths, Co-infection, Th2 response, Immunomodulation.

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