Editorial Open Access
Volume 4 | Issue 1 | DOI: https://doi.org/10.46439/rheumatology.4.025
Exploring novel therapeutic avenues for arthritis precision medicine: The potential of mTOR-SIRT1, NRF2, GPX4 ferroptosis- and autophagy- related pathways and emerging technologies
Bohong Gao1,2,#, Zhihua Yin1,#, Yue Zhang1,3,4,5,*
- 1Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, Guangdong, China
- 2Xijing Hospital of Air Force Military Medical University, Xian, China
- 3Hezhou (the City of Longevity) Dongrong Yao Medicine Research Institute, Joint Institute of Shenzhen University and Hezhou Hospital for Traditional Chinese Medicine, Hezhou, Guangxi, China
- 4Department of Rheumatology and Immunology, The First Clinical College of Harbin Medical University, Harbin, Heilongjiang, China
- 5Integrated Chinese and Western Medicine Research Institute, TORAMI Matrix Longevity and Healthcare hub, Zheng He Hospital, Changsha, Hunan, China
- #Contributed equally
Corresponding Author
Yue Zhang, toronto101@163.com
Received Date: August 07, 2024
Accepted Date: October 03, 2024
Gao B, Yin Z, Zhang Y. Exploring novel therapeutic avenues for arthritis precision medicine: The potential of mTOR-SIRT1, NRF2, GPX4 ferroptosis - and autophagy- related pathways and emerging technologies. Curr Rheumatol Res. 2024;4(1):28-32.
Copyright: © 2024 Gao B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
mTOR: A possible therapeutic target against SARS-CoV-2 infection
The recent pandemic of SARS-CoV-2 has emerged as a health emergency to develop effective therapeutic strategies for restricting deadly disease, COVID-19. SARS-CoV-2 infects cells by the endocytosis process via receptor-mediated binding and priming by cellular proteases.
Dexmedetomidine’s influence on autophagy and its possible link to the cholinergic anti-Inflammatory pathway
Anesthesia and surgical interventions may induce cognitive impairments, such as postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) [1]. These dysfunctions particularly affect the elderly population [2] and increase morbidity and mortality thus representing a major burden for the healthcare system [1].
Osteoarthritis in older adults: Disability associations and the corona virus
Background: Osteoarthritis, a widespread highly painful oftentimes incapacitating joint disease continues to impose immense personal and societal challenges among adults of all ages, especially older adults.
Objective: This review aimed to describe the extent to which older adults with osteoarthritis may suffer excess disability, compared to healthy age-matched older adults, and why this is important to note and prevent in the context of the novel COVID-19 corona virus pandemic.
CD133 and centrosomes: How CD133 inhibits autophagy and induces the undifferentiated state of cancer cells at centrosomes
CD133 is a transmembrane protein that mainly localizes to the plasma membrane of normal stem cells as well as cancer stem cells, and is widely known as a cancer stem cell marker. CD133 was recently shown to localize in the cytoplasm; however, its transport pathway and functions currently remain unknown.
Exploring novel therapeutic avenues for arthritis precision medicine: The potential of mTOR-SIRT1, NRF2, GPX4 ferroptosis- and autophagy- related pathways and emerging technologies
Arthritis remains a common and debilitating disease affecting millions of people worldwide. Osteoarthritis (OA) and rheumatoid arthritis (RA) are among the most common forms of this chronic, degenerative disease, which is moving toward precision medicine.