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Original Research Open Access

Identification of MC4R mutations in obese subjects from Southern India

  • 1Department of Microbiology, Lankapalli Bullayya College, Visakhapatnam 530013, India
  • 2Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, Visakhapatnam 530002, India
  • 3Department of Internal Medicine, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam 530048, India
+ Affiliations - Affiliations

Corresponding Author

Gumpeny Ramachandra Sridhar, grsridhar@hotmail.com

Received Date: August 29, 2025

Accepted Date: September 19, 2025

Abstract

Background: Obesity, which is increasing world-wide results from an interaction of genetic and environmental factors. Monogenic obesity which is rare is currently identified by gene sequencing. Drug therapy is available for these specific subsets of genetic obesity.

Aim: To identify MC4R mutations in obese subjects presenting to an obesity center in southern India.

Methods: Twenty consecutive subjects with obesity underwent sequencing for MC4R gene along with other routine biochemical parameters.

Results: Among 20 subjects, two were shown to have MC4R gene mutants. Both were women, with a body mass index above 40 (Class 3 obesity).

Conclusion: MC4R mutations in subjects with Class 3 obesity were reported from southern India.

Keywords

Syndromic obesity, Mutation, Diagnosis, Screening, Setmelanotide, Price, Accessibility

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