Proximal humerus fracture with simultaneous shoulder dislocation in children is a rare occurrence, with few reported cases. This systematic review of case reports aimed to document the outcomes of different treatment methods. A comprehensive literature search from 1980 to 2024 included case reports on traumatic shoulder fracture-dislocation in children. Eighteen studies were included, with a mean followup of 1.5 years. The cases comprised 7 boys and 11 girls, aged between 11 months and 16 years (median 6 years). The cases were divided into two groups based on epiphysealinvolvement.

The extent of side effects or toxicity depends on the dose and can vary from subject to subject and from treatment to treatment. It is important to note that many of the side effects are temporary, decreasing and/or gradually disappearing in the days following administration or discontinuation of treatment.

In normal cells, homologous recombination (HR) is strictly regulated and precise and plays an important role in preserving genomic integrity by accurately repairing DNA damage. RAD51 is the recombinase which mediates homologous base pairing and strand exchange during DNA repair by HR. We have previously reported that HR is spontaneously elevated (or dysregulated) in esophageal adenocarcinoma (EAC) and contributes to ongoing genomic changes and instability. The purpose of this study was to evaluate the impact of RAD51 inhibitor on genomic toxicity caused by etoposide, a chemotherapeutic agent.

Until recently, eating food has usually been regarded as a low risk activity. In the last century, industrialization has changed methods and chemicals used in the food supply chain to improve production, maintenance, and acceptance by consumers. Hazardous substances can be used in these processes. However, despite the many potential health risks associated with food, in practice, the degree of risk associated with modern food supply is extremely low. The presence and levels of hazardous substances in food, such as chemicals intentionally added, or contaminants and residuals, is constantly monitored and evaluated by national and international agencies assuring safe foodstuff to the public.

Heart disease is one of the top causes of healthcare expenses in the United States. Lethal ventricular cardiac arrhythmia can arise in acquired or congenital heart disease. Long QT syndrome type 3 (LQT3) is a congenital form of ventricular arrhythmia caused by mutations in the cardiac sodium channel SCN5A. Mexiletine is a Class 1 antiarrhythmic drug that inhibits INa-L and shortens the QT interval in LQT3 patients. However, slightly above therapeutic doses, Mexiletine prolongs the cardiac action potential. Mexiletine was reengineered in an iterative process called dynamic medicinal chemistry to explore structure activity relationships (SAR) for AP shortening and prolongation of AP kinetics in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).