Case Report Open Access
Volume 2 | Issue 1 | DOI: https://doi.org/10.46439/allergy.2.018
Severe SARS-CoV-2 infection treated with the mannose binding lectin associated serine protease 2 (MASP2) inhibitor Narsoplimab
Michael D. Knierman1, Valentina Gelfanova1, Neil A. Zlatniski2, John H Mullen1, Robert W. Siegel1, Robert J. Konrad1,*
- 1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
- 2Brownsburg North Family Medicine, Brownsburg, IN 46112, USA
Corresponding Author
Robert J. Konrad, M.D, konrad_robert@lilly.com
Received Date: March 15, 2021
Accepted Date: April 29, 2021
Knierman MD, GelfanovaV, Zlatniski NA, Mullen JH, SiegelRW, Konrad RJ. Severe SARS-CoV-2infection treated with the mannose binding lectin associated serineprotease 2 (MASP2) inhibitor Narsoplimab. J Allergy Infect Dis 2021;2(1):24-28.
Copyright: © 2021 Knierman MD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
In SARS-CoV-2 infection, increased inflammation, complement activation, and excessive clotting are responsible for morbidity and mortality. Recent reports suggest that mannose binding lectin (MBL) and mannose-associated serine protease 2 (MASP2) lies at the intersection of these pathways. Consistent with this concept, we observed that the SARS-CoV-2 spike protein binds MBL-MASP1/2 complex in human serum.
Keywords
SARS-CoV-2, Narsoplimab, COVID-19, MBL, MASP2
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