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Archives of Clinical Toxicology
ISSN: 2692-8280
Featured Articles
RAD51 Inhibitor Reverses Etoposide-Induced Genomic Toxicity and Instability in Esophageal Adenocarcinoma Cells
Chengcheng Lia, Jiangning Zhao, Subodh Kumar, Chandraditya Chakraborty, Srikanth Talluri, Nikhil C. Munshi, Masood A. Shammas
In normal cells, homologous recombination (HR) is strictly regulated and precise and plays an important role in preserving genomic integrity by accurately repairing DNA damage. RAD51 is the recombinase which mediates homologous base pairing and strand exchange during DNA repair by HR. We have previously reported that HR is spontaneously elevated (or dysregulated) in esophageal adenocarcinoma (EAC) and contributes to ongoing genomic changes and instability. The purpose of this study was to evaluate the impact of RAD51 inhibitor on genomic toxicity caused by etoposide, a chemotherapeutic agent.
Arch Clin Toxicol, 2020, Volume 2, Issue 1, p3-9 | DOI: 10.46439/toxicology.2.006]
Non-alcoholic fatty liver disease: Role of PNPLA3 and its association with environmental chemicals
Shakil A Saghir, M.Sc., M.S.P.H., Ph.D., DABT, ERT, Fellow ATS, Fellow RSB, Ata Abbas, Saleh Alfuraih, Ajay Sharma, Jean Latimer, Yadollah Omidi, Rais Ansari, Ph.D.
Non-alcoholic fatty liver disease (NAFLD) represents an escalating global health concern. Its prevalence varies significantly across different regions, in Asia it ranges from 30-32%, with notably higher prevalence in the Middle East. Europe reports a prevalence of 27-33%, while North America shows a range of 35-48%.
Arch Clin Toxicol, 2024, Volume 6, Issue 1, p21-32 | DOI: 10.46439/toxicology.6.029
Toxicological assessment of chondroitin sulfate oligosaccharide
Kara D. Lewis, Michael Falk
Toxicology studies were conducted to evaluate the safety of chondroitin sulfate oligosaccharide (CSO) produced by the enzymatic hydrolysis of shark cartilage by a bacterial lyase. Although the safety of chondroitin sulfate, which is used as a dietary supplement, has been investigated, no safety studies have been conducted on CSO. CSO was evaluated in bacterial reverse mutagenesis, mammalian cell gene mutation using mouse lymphoma cells, in vivo mammalian erythrocyte micronucleus assays, and a ninety-day repeated dose oral toxicity study in rats.
Arch Clin Toxicol, 2023, Volume 5, Issue 1, p40-51 | DOI: 10.46439/toxicology.5.023