The Neuroscience Chronicles

Commentary Open Access

Natural vs. Artificial intelligence, creativity and consciousness in machines

Ivan Sekaj

We compare the selected characteristics and physical parameters of two types of systems capable of intelligent behavior: biological brains and semiconductor computing systems. We analyze their limitations and potential for further development. We then reflect on the creative thinking and capabilities of both approaches and present a cybernetic perspective on brain function and the hypothesis of consciousness in the brain.

Neurosci Chron, 2026, Volume 6, Issue 1, p1-6 | DOI: 10.46439/Neuroscience.6.035

Commentary Open Access

Neuropeptide FF receptor activation as a novel modulator of N-type calcium channel-mediated analgesia: Expanding the therapeutic potential of ziconotide

Guofei Jin , Zhenglan Han

The management of severe, refractory chronic pain remains a major unmet clinical need, complicated by opioid limitations and the narrow therapeutic window of intrathecal ziconotide, a selective N-type voltage-gated calcium channel (CaV2.2) blocker. A recent study by Jin et al. provides the first in vivo evidence that spinal neuropeptide FF (NPFF) receptor signaling functionally cross-talks with CaV2.2 to enhance ziconotide-evoked antinociception without inducing tolerance. 

Neurosci Chron, 2026, Volume 6, Issue 1, p7-10 | DOI: 10.46439/Neuroscience.6.036