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Cell Signaling

ISSN: 2837-8253

Review Article Open Access

A review on molecular mechanisms underlying the contribution of Tspan8 and CD151 tumor and host exosomes to tumor progression, hematopoiesis and angiogenesis

Kun Zhao1,*, Zhe Wang2, Margot Zöller3
  • 1The Seventh Affiliated Hospital, Sun Yat-sen University, China
  • 2Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China
  • 3Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China
+ Affiliations - Affiliations

Corresponding Author

Kun Zhao, zhaokun@sysush.com

Received Date: June 20, 2025

Accepted Date: September 25, 2025

Citation:

Zhao K, Wang Z, Zöller M. A review on molecular mechanisms underlying the contribution of Tspan8 and CD151 tumor and host exosomes to tumor progression, hematopoiesis and angiogenesis.


Copyright: © 2025 Zhao K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Tetraspanins associate with many proteins and are involved in numerous activities like the crosstalk between cells and matrix, tumor progression, angiogenesis, and hematopoiesis. These multiple activities are mostly executed via exosomes (Exo) or tumor-derived Exo (TEX) and are impaired in Tspan8-knockout (ko), CD151ko and Tspan8ko/CD151ko (dbko) mice and cells. Strongly impaired tumor cell dissemination RTK with limited migration and invasion relied on distorted associations with cell adhesion molecules and missing protease recruitment and was rescued by coculture with wild type (wt) Exo. Defects in early hematopoietic progenitor maturation depended on the failed association of hematopoietic growth factor receptors with CD151 and Tspan8. Constrained angiogenesis in ko mice was due to the failure of recruiting GPCR via Tspan8 and CD151. It was rescued by wt Exo. An additive impact of Tspan8ko and CD151ko in dbko cells depended on differences in preferred associations of Tspan8 and CD151. All defects relied on reduced delivery as well as uptake of Exo and TEX by ko cells. Here we did a literature search on the underlying mechanisms.

Keywords

Tspan8 knockout, CD151 knockout, Exosomes, TEX, Metastasis, Angiogenesis, Hematopoiesis

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