Abstract
Living cell could be considered the most sophisticated anti-entropy machinery born in the heart of the strong and ferocious pro-entropy environment of the primordial ocean full of boiling and salty water, some thirty-eight hundred million years ago on this planet. Evolution of prokaryotes with a simple cell membrane to eukaryotes and later on multi-cellular organisms, has necessitated the birth and evolution of a protective microenvironment, which could shield and secure evolution of living organisms by its sophisticated anti-entropy components, including its vasculature, immune modulating and growth promoting genes and molecules. It is easy to conceive that an acquired or genetically inherited defect in each of the protective layers built into the matrix of microenvironment, could potentially open the gate on catastrophic events including neoplastic transformation. Massive interconnectivity of cells and microenvironment, would also allow defects originating in cells to spill into adjacent microenvironment. This, in turn would change an anti-entropy microenvironment into a pro-entropy one, perpetuating a vicious cycle. As such, our future cancer therapeutics should be based on deep understanding of these fundamental principles and their perturbations. Such understanding, would open the way on design of future cancer therapeutics.
Keywords
Cancer, Microenvironment, Entropy, Programmable nano-machines, Inflammation, Telomere