Commentary Open Access
Volume 1 | Issue 1 | DOI: https://doi.org/10.46439/pediatrics.1.004
Commentary on "Empirical profile Bayesian estimation for extrapolation of historical adult data to pediatric drug development"
Yaoshi Wu1,*, Jianan Hui1, Qiqi Deng1
- 1Boehringer-Ingelheim, 900 Ridgebury Rd.,Ridgefield, CT06877, USA
Corresponding Author
Yaoshi Wu, yaoshi.wu@boehringer-ingelheim.com
Received Date: December 11, 2020
Accepted Date: January 22, 2021
Wu Y, Hui J, Deng Q. Commentary on “Empirical profile Bayesian estimation for extrapolation of historical adult data to pediatric drug development”. J Clin Pediatr Neonatol. 2021; 1(1):21-22.
Copyright: © 2021 Wu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
Acanthamoeba keratitis - is there another perspective: Extrapolations from the Acanthamoeba – fungal keratitis study
Identified only in 1974 as an etiological agent of keratitis [1] and occurring primarily in contact lens wearers, Acanthamoeba keratitis (AK) occupies a unique niche in microbial keratitis because of its propensity to be misdiagnosed, the paucity of therapeutic options, as well as its recalcitrance to standard medical therapy. Moreover, the tendency of the organism to form cysts under adverse circumstances (that are resistant to amebicides and extremes of temperature) makes eradication of the infection very challenging.
Commentary on "Empirical profile Bayesian estimation for extrapolation of historical adult data to pediatric drug development"
We are writing to promote a novel Bayesian dynamic borrowing approach, the empirical profile Bayesian estimation, in the published article "Yaoshi Wu, Jianan Hui, Qiqi Deng. Empirical profile Bayesian estimation for extrapolation of historical adult data to pediatric drug development. Pharmaceutical statistics 2020; 19; 787-802. http://dx.doi.org/10.1002/pst.2031."
The importance of assessing a family’s information-sharing strategy in pediatrics
In “Family Strategies to Support Siblings of Pediatric Hematopoietic Stem Cell Transplant Patients”, we described the 10 strategies used by families to support siblings. One of the strategies was sharing information. Interestingly, only about one third of the parents (Fathers (7/21, 33.3%), and Mothers (8/20, 40%)) indicated that they shared information with the patient about the transplant decision while over half of the children (10/17, 59%) reported that information was shared with them.