Skin aging is related to intrinsic or chronological and extrinsic or environmental factors. Oxidative stress, with generation of Reactive Oxygen Species (ROS), occurs during oxidative cell metabolism, mostly on mitochondria, and it is aggravated by chronic exposition to Ultra-Violet (UV)B (short wavelength) and UVA (long wavelength) sun radiations.

Traditional Chinese Medicine (TCM), the world’s oldest known herbal medicine, has long been used in several Asian countries. Emerging evidence has demonstrated their effectiveness and safety in the treatment of various diseases, ranging from mild flu to severe cancers. A great number of patients have benefited by receiving TCM therapies. However, due to the complex chemical compositions of TCM, which could produce highly complex compound-protein binding interactions, the molecular mechanisms underlying the pharmacological actions of TCM still remain poorly understood. Specifically, it is difficult to identify and isolate the effective constituents from the mixture of many compounds, even the therapeutic targets are known.

Inflammation is a complex biological process essential for protecting the body from harmful stimuli. However, dysregulated or chronic inflammation can contribute to the pathogenesis of various diseases, including asthma, rheumatoid arthritis, and gout. Pro-inflammatory enzymes, such as arachidonate 5-lipoxygenase (A5-LOX), xanthine oxidase, and hyaluronidase, play key roles in the initiation, progression, and resolution of inflammation.

Background: Cutis verticis gyrata (CVG) is characterized by excessive skin folding on the scalp and can be classified into primary essential, primary nonessential, and secondary. While most cases are asymptomatic, some patients seek treatment due to cosmetic concerns. The primary objective of this case study was to evaluate the efficacy of intradermal hyaluronidase for cutis verticis gyrata of the scalp in the presented patient.