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Commentary Open Access
Volume 1 | Issue 1 | DOI: https://doi.org/10.46439/signaling.1.009

Do arrestin oligomers have specific functions?

  • 1Gurevich VV. Do arrestin oligomers have specific functions?
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Corresponding Author

Vsevolod V. Gurevich, vsevolod.gurevich@vanderbilt.edu

Received Date: July 21, 2023

Accepted Date: July 27, 2023

Abstract

Arrestins are a small family of versatile regulators of cell signaling. Arrestins regulate signaling and trafficking of G protein-coupled receptors, regulate and direct to particular subcellular compartments numerous protein kinases, ubiquitin ligases, etc. Three out of four arrestin subtypes expressed in vertebrates self-associate, each forming oligomers of a distinct size and shape. While the structures of the solution oligomers of arrestin-1, -2, and -3 have been elucidated, no function specific for the oligomeric form of either of these three subtypes has been identified thus far. Considering how multi-functional average-sized (~45 kDa) arrestin proteins were found to be, it appears likely that certain functions are predominantly or exclusively fulfilled by monomeric and oligomeric forms of each subtype.

Keywords

Arrestin, GPCR, Cell signaling, Oligomers

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