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Journal of Experimental and Molecular Pathology

ISSN: 3068-031X

Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/pathology.3.010

FEN1 drives small cell neuroendocrine carcinoma of the cervix progression and holds promise as a therapeutic target

Haixia Ma4, Meiying Zhong1, Kai Yang1, Jianbing Liu1,2,3,*
  • 1Shanxi Medical University, School of Basic Medical Sciences, Taiyuan, 030001, China
  • 2The Second Hospital of Shanxi Medical University, Departments of Obstetrics and Gynecology, Taiyuan, 036000, China
  • 3Shanxi Key Laboratory of Functional Proteins, Shanxi Medical University, Taiyuan, 030001, China
  • 4Shanxi Province Cancer Hospital, Department of Pathology, Taiyuan, 030013, China
+ Affiliations - Affiliations

Corresponding Author

Jianbing Liu; liujianbing@sxmu.edu.cn

Received Date: October 30, 2025

Accepted Date: January 07, 2026

Citation:

Ma H, Zhong M, Yang K, Liu J. FEN1 drives small cell neuroendocrine carcinoma of the cervix progression and holds promise as a therapeutic target. J Exp Mol Pathol. 2026;3(1):1-3.


Copyright: © 2026 Ma H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Small cell neuroendocrine carcinoma of the cervix (SCNECC) is a rare and clinically aggressive subtype of cervical cancer associated with a poor prognosis. To investigate its underlying pathological mechanisms and identify potential therapeutic targets, researchers have increasingly employed single-omics or multi-omics integrated analysis, including single-cell transcriptome sequencing, proteomics, whole-exome sequencing, and genomics. In a study by Jianbing Liu et al., proteomic profiling of SCNECC tumor tissues and adjacent non-tumor tissues revealed that FEN1 drives disease progression by modulating PCNA expression. FEN1 shows promise as a novel therapeutic target for SCNECC. This commentary emphasizes that omics technology is an effective research approach for investigating the pathological mechanisms of SCNECC, and FEN1 shows potential as a novel therapeutic target for SCNECC. However, further experiments are required to elucidate its mechanisms of action.

Keywords

Small cell neuroendocrine carcinoma of the cervix, SCNECC, Proteomics, FEN1, Targeted therapy

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