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Research Article Open Access
Volume 1 | Issue 1 | DOI: https://doi.org/10.46439/nutrition.1.003

Glucan and Vitamin D supplementation showed synergy in improvements of the immune response against an influenza challenge in mice

  • 1University of Louisville, Department of Pathology, Louisville, KY, USA
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Corresponding Author

Vaclav Vetvicka, Vaclav.vetvicka@louisville.edu

Received Date: June 01, 2020

Accepted Date: June 29, 2020

Abstract

Influenza infection remains a serious health problem throughout the world. Unfortunately, current medicine offers no real treatment or protection, moving our attention to alternative options. In this study we aimed to evaluate the possible effects of a combination of glucan and vitamin C on immunosuppression caused by influenza infection. We found that supplementation with this combination significantly improved overall survival and selected immune mechanisms such as phagocytosis, NK cell activity, production of some cytokines and antibody response. Based on our data we can conclude that the positive effects of the glucan-vitamin D combination are based on stimulation of both humoral and cellular immune reaction and result in significant lowering of the viral load.

Keywords

Glucan, influenza, immune system, virus

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