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Cell Signaling

ISSN: 2837-8253

Commentary Open Access
Volume 4 | Issue 1 | DOI: https://doi.org/10.46439/signaling.4.095

Immune–pigment dynamics in uveal melanoma

Jayanti Jha1, Mithalesh Kumar Singh2, Lata Singh3, Neelam Pushker4, Aanchal Kakkar5, Rachna Meel4, Neiwete Lomi4, Sameer Bakhshi6, Tapas Chandra Nag7, Chanda Panwar7, Seema Sen1, Seema Kashyap1,*
  • 1Department of Ocular Pathology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Delhi, India
  • 2Department of Ophthalmology, UT Southwestern Medical Center, Dallas, USA
  • 3Department of Paediatrics, All India Institute of Medical Sciences, Delhi, India
  • 4Department of Ophthalmology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Delhi, India
  • 5Department of Pathology, All India Institute of Medical Sciences, Delhi, India
  • 6Department of Medical Oncology, All India Institute of Medical Sciences, Delhi, India
  • 7Department of Anatomy, All India Institute of Medical Sciences, Delhi, India
+ Affiliations - Affiliations

Corresponding Author

Seema Kashyap, dr_skashyap@hotmail.com

Received Date: January 23, 2026

Accepted Date: March 12, 2026

Citation:

Jha J, Singh MK, Singh L, Pushker N, Kakkar A, Meel R, et al. Immune–pigment dynamics in uveal melanoma. Cell Signal. 2026;4(1):44-46.


Copyright: © 2026 Jha J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In uveal melanoma (UM), increased M2 macrophage infiltration and high tumor pigmentation are well-established adverse prognostic features, yet their biological interplay remains underexplored. Emerging evidence indicates that these characteristics frequently coexist in genetically high-risk tumors, particularly those with monosomy 3 and BAP1 loss. This commentary proposes that highly pigmented tumor cells and M2-polarised macrophages form an integrated, immunosuppressive tumor ecosystem that promotes immune tolerance and tumor progression. Recognizing immune–pigment coexistence provides a refined framework for prognostic assessment and highlights microenvironmental interactions as potential targets for future therapeutic strategies in UM. Understanding these dynamics may improve risk stratification and development of targeted therapies.

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