Mini Review Open Access
Molecular network regulation and precision therapy frontiers in osteoarthritis: from ferroptosis to autophagy metabolic reprogramming
Yue Zhang1-5,#,*, Huichang Zhang1,#, Xiaoying Zhu1,2,#, Bohong Gao1,#, Kamel Meguellati6,*, Cibo Huang7,8,*
- #Contributed equally
- 1Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, Guangdong, China
- 2Department of Rheumatology and Immunology, The First Clinical College of Harbin Medical University, Harbin, China
- 3Shenzhen Weilan Translational Institute of Biomicromolecules Research, Shenzhen, Guangdong, China
- 4Hezhou Dongrong Yao Medicine Research Institute, Joint Institute of Shenzhen University and Hezhou Hospital for Traditional Chinese Medicine, Hezhou, Guangxi, China
- 5Integrated Chinese and Western Medicine Research Institute, TORAMI Avatar Longevity and Healthcare Hub, Zheng He Hospital, Changsha, Hunan, China
- 6College of Pharmacy, Jinan University, Guangzhou, China
- 7Department of Rheumatology, Immunology and Gerontology, South- China Hospital of Shenzhen University, Shenzhen, China
- 8Department of Rheumatology and Immunology, National Center of Gerontology, Beijing Hospital, Beijing, China
Corresponding Author
Yue Zhang, humanoids101@163.com; Kamel Meguellati, kameljilin@yahoo.fr; Cibo Huang, huangcibo1208@139.com
Received Date: November 06, 2025
Accepted Date: December 30, 2025
Zhang Y, Zhang H, Zhu X, Gao B, Meguellati K, Huang C. Molecular network regulation and precision therapy frontiers in osteoarthritis: from ferroptosis to autophagy metabolic reprogramming. J Biomed Res. 2026;7(1):13-16.
Copyright: © 2026 Zhang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Osteoarthritis (OA), the most prevalent degenerative joint disease, involves intricate molecular interactions across joint tissues. This review highlights advancements in understanding OA pathogenesis, focusing on the ferroptosis-autophagy axis and the therapeutic potential of Coenzyme Q10 (CoQ10). By integrating and reviewing multi-omics technologies, novel diagnostic tools, and targeted therapies, this review underscores the shift toward precision medicine in OA management.
Keywords
Osteoarthritis, Ferroptosis, Metabolic reprogramming, CoQ10
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