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Journal of Allergy and Infectious Diseases

ISSN: 2692-6334

Review Article Open Access
Volume 2 | Issue 3 | DOI: https://doi.org/10.46439/allergy.2.025

Nonstructural proteins of SARS-CoV-2

Jason Y Tang1, Igor F. Tsigelny2,3,4,*, Valentina L. Kouznetsova2,4
  • 1REHS and MAP program, San Diego Supercomputer Center, University of California at San Diego, La Jolla, California, USA
  • 2San Diego Supercomputer Center, University of California at San Diego, La Jolla, California, USA
  • 3Department of Neurosciences, University of California at San Diego, La Jolla, California, USA
  • 4BiAna. San Diego, California, USA
+ Affiliations - Affiliations

Corresponding Author

Igor F. Tsigelny, itsigeln@ucsd.edu

Received Date: June 20, 2021

Accepted Date: August 17, 2021

Citation:

Tang JY, Tsigelny IF, Kouznetsova VL. Nonstructural Proteins of SARS-CoV-2. J Allergy Infect Dis 2021; 2(3):52-65.


Copyright: © 2021 Tang JY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

COVID-19 is a serious global health threat caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus enters human host cells through the recognition of angiotensin converting enzyme 2 (ACE2) receptors or cluster of differentiation 147 (CD147) via the virus’s spike glycoprotein. Once inside the cell, SARS-CoV-2 uses its genomic RNA as template to produce the two overlapping polyproteins, pp1a and pp1ab, that are subsequently cleaved into 16 nonstructural proteins (NSPs). NSPs then form a replication–transcription complex (RTC) to generate new viral RNA genomes and the mRNAs essential for viral replication. Thus, NSPs can be good targets for the development of antiviral drugs against SARS-CoV-2 infection. Here, we review the nonstructural proteins of SARS CoV 2, focusing on their protein structure and function.

Keywords

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, Nonstructural proteins (NSPs), Antiviral

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