Background and Aim: Non-Alcoholic Fatty Liver Disease (NAFLD) is the commonest cause of chronic liver disease and is a leading cause of liver transplantation in the United States, with no approved medication to halt or reverse its progression. Recent animal-model prospective trial-suggested that drug Vedolizumab leads to improvement and reversal in the NAFLD-related metabolic derangements. Vedolizumab is an α4β7 integrin-inhibitor that is approved for use in IBD patients. Our study aims to understand Vedolizumab's impact on the course of NAFLD in inflammatory bowel disease (IBD) patients.

Non-Alcoholic Fatty Liver Disease (NAFLD) is the growing epidemic which is rapidly increasing in USA. Elderly people are the most affected population which suffers from NAFLD. The earliest stage of NAFLD, hepatic steatosis has no evidence of liver injury, but is characterized by an accumulation of triglycerides in hepatocytes. Hepatic steatosis progresses in age-dependent manner to non-alcoholic steatohepatitis (NASH) and cirrhosis. Mechanisms of development of age associated NAFLD are not well understood and approaches to treat this disease are not developed. Recent studies within last three years; however, provided several lines of evidence showing that although hepatic steatosis strongly correlates with development of NAFLD, it might be not a cause of next steps of NAFLD: fibrosis and NASH. Moreover, some reports suggest that hepatic steatosis might play a protective role in development of fibrosis and NASH. Recent studies of NAFLD in animal models showed that the increase of liver proliferation is the first event in high-fat diet-induced NAFLD.

A strong intergenerational divide in voting behaviour has become a frequently reported stylized fact in post-referendum analyses, raising the question of whether myopia of elderly voters is a cause for concern in ageing societies. However, identifying the origins of a generation gap is empirically challenging because age and birth cohort are collinear at any given point in time. Building on a previous study, we summarize how this problem can be overcome. We discuss an unconstrained rank regression approach that allows estimating the causal ageing effect on political attitudes conditional on arbitrary cohort effects in a flexible manner.

The use of administrative databases to determine predictors for heart failure (HF) readmission, cardiovascular, or all-cause mortality (ACM) requires HF coding that is verifiable. It is assumed that administrative databases have HF verified via coders based on physician documentation and additional criteria.

We have made an extensive study of the development of picky eating behavior in childhood, and its effects on diet and growth, using data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Mothers were recruited during pregnancy in 1991/2 and they and their child have been followed using questionnaires plus measurements at research clinics from infancy onwards. A wealth of information was collected prospectively about feeding the child in their first 1000 days and beyond. Questions were asked at regular intervals about difficulties parents had in feeding their child and how they responded to these difficulties.