Journal of Breast Cancer Research

Brain metastases are a feared complication of breast cancer, occurring in 15-25% of patients and being associated with poor prognosis and reduced quality of life. Magnetic resonance imaging (MRI) is an advanced technique that uses powerful magnetic fields and radio waves to produce detailed three-dimensional (3D) images of the brain's neuroanatomy and any potential pathology, especially in the management of brain metastases. The review article by Mohammadi et al. provides a timely and comprehensive overview of the utility of MRI for detecting and characterizing brain metastases from breast cancer. 

The epidermal growth factor receptor (EGFR) is a member of the ErbB family. It is involved in biological processes such as cell proliferation, angiogenesis, inhibition of apoptosis, adhesion, metastasis, and is associated with the progression of lung cancer [1-3].

Breast cancer is the second most common cancer in the world and the most common cancer among women. The most common presenting symptoms are a painless subareolar lump, nipple retraction, and bleeding from the nipple. 

BC, a heterogeneous disease, is thought to be the second leading cause of death in women globally. In only 70-80% of the BC patients with early-stage, non-metastatic disease is curable [1]. In advanced BC metastasis, it is incurable [2]. 

Breast cancer is the most common cancer in women worldwide, with the highest mortality rates. While breast tumors can have heterogeneous biology, the mutational burden/genomic alterations, etc, are relatively less when compared to other malignancies like pancreatic cancer or glioblastomas, rendering breast tumors comparatively less aggressive.