Commentary Open Access
Volume 4 | Issue 2 | DOI: https://doi.org/10.46439/cancerbiology.4.055
Turn up the MIC(A/B): Amplifying stress-ligand recognition to target iPSC derived immune cell therapies against tumors and diseased cell states
John Goulding1,*, Alejandro J. Garcia1, Martin P. Hosking1, Peter Szabo1, Bahram Valamehr1,*
- 1Fate Therapeutics Inc., San Diego, CA, 92131, USA
Corresponding Author
John Goulding, bobby.goulding@fatetherapeutics.com ; Bahram Valamehr, bob.valamehr@fatetherapeutics.com
Received Date: December 10, 2023
Accepted Date: December 20, 2023
Goulding J, Garcia AJ, Hosking MP, Szabo P, Valamehr B. Turn up the MIC(A/B): Amplifying stress-ligand recognition to target iPSC derived immune cell therapies against tumors and diseased cell states. J Cancer Biol. 2023;4(2):49-53.
Copyright: © 2023 Goulding J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recommended Articles
Fight tumor heterogeneity
Intratumor heterogeneity has attracted more and more attention in recent years. Heterogeneity is the driving force of tumor clone evolution. Chromosomal instability, somatic mutation, epigenetic modification and extrachromosomal DNA (ecDNA) contribute to tumor heterogeneity. The degree of such heterogeneity is extremely high.
Modulating the immunotolerant tumor microenvironment to enhance irreversible electroporation ablation therapy
Over the years, several ablation techniques, such as radiofrequency ablation (RFA), microwave ablation, and cryoablation, have been developed and implemented in the treatment of different cancers. Of these ablation technologies, RFA is the most widely used. RFA is a form of thermal ablation that relies on radio waves to produce an electrical current at the tip of an inserted electrode, thus allowing for heat production at the site of the tumor.
The tumor dose sensitivity matrix and stem cells in head and neck cancer
Radiation therapy (RT) is one of the pillars of locally advanced head and neck cancer (HNSCC) treatment in combination with cisplatin or epidermal growth factor receptor inhibitors. Despite a very high local tumor control rate, approximately 50% of patients with locally advanced disease will develop a recurrence.
Genetic mutations in the molecular pathogenesis of gastrointestinal stromal tumor
Gastrointestinal stromal tumors are mesenchymal tumors which predominantly originate from the interstitial cells of Cajal in the intestinal lining. Around ~85% of malignant GISTs possess activating mutations in the tyrosine kinase receptors KIT or PDGFRA. The driver mutations in genes other than KIT or PDGFRA account for around 15% GISTs and belong to highly heterogeneous groups called wild-type GISTs. Around 20–40% of WT-GISTS are deficient for the succinate dehydrogenase complex (SDHA, SDHB, SDHC, SDHD).
Approach to testicular adrenal rest tumors in children and adolescents with congenital adrenal hyperplasia
Congenital adrenal hyperplasia (CAH) is a disorder affecting cortisol biosynthesis in the adrenal cortex [1]. 21-hydroxylase deficiency is the most frequent reason for CAH, with an incidence between 1:10.000 and 1:20.000 [2]. Due to the lack of enzyme function, patients with any enzyme deficiency cannot synthesize cortisol effectively.