Archives of Clinical Toxicology

Research Article Open Access

RAD51 Inhibitor Reverses Etoposide-Induced Genomic Toxicity and Instability in Esophageal Adenocarcinoma Cells

Chengcheng Lia, Jiangning Zhao, Subodh Kumar, Chandraditya Chakraborty, Srikanth Talluri, Nikhil C. Munshi, Masood A. Shammas

In normal cells, homologous recombination (HR) is strictly regulated and precise and plays an important role in preserving genomic integrity by accurately repairing DNA damage. RAD51 is the recombinase which mediates homologous base pairing and strand exchange during DNA repair by HR. We have previously reported that HR is spontaneously elevated (or dysregulated) in esophageal adenocarcinoma (EAC) and contributes to ongoing genomic changes and instability. The purpose of this study was to evaluate the impact of RAD51 inhibitor on genomic toxicity caused by etoposide, a chemotherapeutic agent.

Arch Clin Toxicol, 2020, Volume 2, Issue 1, p3-9 | DOI: 10.46439/toxicology.2.006]

Commentary Open Access

Valproate, Topiramate, and emerging neurodevelopmental concerns

Chiara Gazerro, Carla Landolfi

Our brain is the most intricated organ of our body. It is, therefore, unsurprising that external factors to which the fetus is exposed to during its development, such as drugs, alcohol, environmental toxicants, and medicines may have lasting effects that extend into adulthood [1,2].

Arch Clin Toxicol, 2024, Volume 6, Issue 1, p16-18 | DOI: 10.46439/toxicology.6.027

Review Article Open Access

Non-alcoholic fatty liver disease: Role of nuclear receptor superfamily members and approaches to treatment

Siddique Rezan Mohammed, Shakil A Saghir, M.Sc., M.S.P.H., Ph.D., DABT, ERT, Fellow ATS, Fellow RSB, Saleh Alfuraih, Abdulaziz Khalid Salamatullah, Faisal Fahad Alnefaie, Samirah Khan, Syed A. A. Rizvi, Rais Ansari, Ph.D.

Non-alcoholic fatty liver disease (NAFLD) is an increasing health problem when left untreated. NAFLD is defined as accumulation of fat in 5% of the hepatocytes. NAFLD can convert into non-alcoholic steatohepatitis (NASH) which is defined as inflammatory NAFLD. Both NAFLD and NASH are observed in individuals suffering from metabolic syndrome and type 2 diabetes (T2D).

Arch Clin Toxicol, 2024, Volume 6, Issue 1, p48-61 | DOI: 10.46439/toxicology.6.031