Archives of Clinical and Experimental Ophthalmology

Commentary Open Access

From observation to diagnosis: Implications of calcified sclero-choroidal choristomas in mosaic RASopathies

Brian M Grodecki, Saipriya C Potluri, Karl Olsen, Amgad Eldib, Hannah L Scanga, Matthew S Pihlblad, Ken K Nischal

The identification of calcified sclero-choroidal choristomas (CaSCCs) in patients with mosaic RASopathies introduces a new dimension to understanding ocular manifestations in these genetic disorders.

Letter to the Editor Open Access

Presbyopia correcting IOLs and the ocular surface disease… The good, the bad and the ugly

Slavomir Kirilov

The last two decades were especially fruitful for the refractive surgeons and for the industry who have been showing tremendous development in both understanding and meeting patients’ desire for spectacle independence. Ever since the first trials from Dr. Kenneth Hoffer with his early 1980’s effort in producing a multifocal IOL to the latest achievements from different companies in putting trifocals and EDOF optics to the market.

Short Communication Open Access

MSICS is a Simple Solution for a Big Problem

Mohamed. A. Almousa

Manual small-incision cataract surgery (MSICS) is a sutureless cataract surgery that has multiple advantages over traditional phacoemulsification and extracapsular cataract extraction (ECCE) procedures. SICS became the procedure of choice for international ophthalmology, where the microscopes and operating room can be more challenging, in addition to the more advanced pathology often seen.

Research Article Open Access

Involvement of TGFβ signaling pathway in oxidative stress and diabetic retinopathy

Reanna Rodriguez, Kristine Lowe, Megan Keniry, Andrew Tsin

Diabetic Retinopathy (DR) is a leading cause of blindness in the U.S. However, not much is known of underlying molecular mechanism and how oxidative stress contributes to its development. In the present study, we investigated the involvement of TGFβ signaling pathway on the effect of oxidative stress on VEGF secretion and viability of retinal cells. VEGF is the hallmark that exacerbates DR progression in prolonged diabetes. Some major concerns that have arisen are the underlying effects of antioxidants in elevating VEGF secretion in diabetes.

Short Communication Open Access

Recent advances on visual cycle protein research and progress on clinical translation

Xin Yee Ooi, Rujman Khan, Anjalee Choudhury, Francisco Xavier Elisarraras, Jeff Grigsby, Brandi Obregon, Andrew Tsin

Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP.