Journal of Pain Research and Management

Original Research Open Access

The involvement of nitrergic pathway in the peripheral antinociceptive action of epoxyeicosatrienoic acids (EETs)

Flávia C.S. Fonseca , Walace C.P. Barra , Daniel P.D. Machado , Douglas L. de Almeida , Danielle D. Aguiar , Bárbara F.G. de Queiroz , Andrea C. Perez , Thiago R.L. Romero , Igor D.G. Duarte

Our group has described the nitrergic pathway as a key analgesic mechanism of drugs and as part of the endogenous control of peripheral inflammatory pain. Studies have shown that epoxyeicosatrienoic acids (EETs) can activate different isoforms of nitric oxide synthase, leading to nitric oxide release and subsequent vasodilation. 

Original Research Open Access

Antinociceptive effect of N,N-dimethyltryptamine (DMT) involving serotonergic, opioidergic, cannabinoidergic, and nitrergic systems in PGE2-induced hyperalgesia in rats

Flávia C.S. Fonseca , Daniel P.D. Machado , André D. Cavalcante , Andrea C. Perez , Thiago R.L. Romero , Igor D.G. Duarte

N,N-dimethyltryptamine (DMT) is an alkaloid structurally similar to serotonin that acts on serotonergic receptors. This study aimed to evaluate the effects of DMT on peripheral nociception and explore its possible mechanisms of action. Male Wistar rats underwent a mechanical paw pressure test, with hyperalgesia induced by intraplantar injection of prostaglandin E2 (PGE2; 2 µg/paw). 

Editorial Open Access

AI enhances clinicians managing surgical causes of pain

Hazim Abdul Rahman Alhiti

AI has become increasingly important in surgery due to its potential to enhance precision, efficiency, and patient outcomes. AI enhances clinicians' ability to manage surgical causes of pain in several impactful ways.

Perspective Open Access

From subjective scores to structured stratification: development of the Objective Pain Assessment Scale (OPAS): a clinical observation

Paul Dranichnikov

Pain assessment remains a fundamental yet challenging component of clinical practice. The Visual Analog Scale (VAS) is widely used pain assessment tool in research and clinical practice; however, reliance on a unidimensional self-reported numeric score risks oversimplifying a complex and multidimensional experience.

Letter to the Editor Open Access

Physical activity and quality of life in statin users

Vimal Tyagi , Sajjan Pal

We read with interest the article by Mert Er et al., “Physical activity and quality of life in statin users,”. The topic is clinically important given persistent concerns regarding statin-associated muscle symptoms (SAMS) and their potential impact on adherence and lifestyle behaviors. However, several conceptual and methodological considerations warrant closer examination.