Journal of Pain Research and Management

Fibromyalgia (FM) is usually considered a ‘medically unexplained’ chronic pain disorder with no known causal treatment. The disorder is also referred to as a ‘functional somatic syndrome’ in which psychological factors are believed to play an important role. According to recent criteria of the American College of Rheumatology (ACR), the main symptom is unexplained widespread pain for at least 3 months; associated symptoms include fatigue, impaired concentration, non-restorative sleep, stimulus intolerance, post-exertional malaise, and various complaints related to neuro-vegetative dysfunction.

Pain is one of the most common symptoms experienced by patients undergoing coronary artery bypass graft (CABG) surgery. Adequate pain management is critical to the well-being and overall recovery of these patients. This study aimed to evaluate the effect of preoperative in-person pain education on the pain severity experienced by patients undergoing CABG surgery in Rajaie Cardiovascular, Medical and Research Center in Tehran in 2022. In this quasi-experimental study, 72 patients undergoing coronary artery bypass surgery were selected and randomly divided into intervention (n=36) and control (n=36) groups.

Pain represents a significant global health issue with serious consequences for both individual well-being and societal functioning. The International Association for the Study of Pain (IASP) characterizes pain as an "unpleasant sensory and emotional experience linked to actual or potential tissue damage".

Orofacial pain represents a significant portion of the complaints from patients seeking treatment at pain management centers worldwide. Although the treatment for orofacial pain is primarily pharmacological, there has been an increase in reports showing significant clinical results from non-pharmacological therapies, including electroacupuncture (EA).

As of 2024, adults aged 65 and older account for over 10% of the global population, nearly double the 1974 figure and still rising. In the island of Puerto Rico, the proportion of older adults has increased greatly, from approximately 13% of the population being over 65 years in 2014, to 24.6% of the population in 2024. 

Chronic pain still remains a complex healthcare challenge impacting millions of people worldwide, demanding innovative solutions to enhance patient outcomes and alleviate the burden towards healthcare systems. This research investigates the transformative potential of Artificial Intelligence (AI) in chronic pain management, emphasizing its application in personalized diagnostics, predictive modeling, and optimized treatment strategies.

Complex Regional Pain Syndrome (CRPS) is a challenging condition marked by intense and often long-lasting pain, typically occurring in a limb following an injury. Traditional treatment approaches might not always offer significant pain relief, prompting the investigation of advanced treatments like Spinal Cord Stimulation (SCS).

Hypnosis, a clinically valuable therapeutic modality, is increasingly recognized for its efficacy in treating a spectrum of psychological and somatic disorders, including pain. Its influence extends beyond central nervous system processes to encompass the autonomic nervous system (ANS), thereby affecting peripheral physiological responses.

Sleep Paralysis (SP) is a complex and multifaceted phenomenon situated at the intersection of neurobiology, psychiatry, genetics, and cultural belief systems. This study offers a comprehensive investigation into SP, integrating findings from neurophysiological, psychological, and sociocultural domains. Neurobiological evidence highlights disruptions during the rapid eye movement (REM) sleep cycle—specifically the persistence of REM atonia into wakefulness—as a core mechanism underlying SP, often accompanied by vivid hallucinations and sensory distortions.

The hyperpolarization of neuronal membranes through the activation of potassium and chloride channels is a significant mechanism involved in the antinociceptive effects of various drugs. Thus, in this study, we aimed to determine whether potassium or chloride channels mediate the peripheral antinociceptive effects of epoxyeicosatrienoic acids (EETs). The mechanical paw pressure test was utilized as an algesimetric method.

This paper analyzes a misdiagnosed case of invasive pulmonary aspergillosis (IPA) presenting with left upper limb pain as an atypical symptom, exploring cognitive blind spots in clinical diagnosis, limitations in imaging and laboratory examinations, and therapeutic challenges. It emphasizes the importance of multidisciplinary collaboration in complex cases.

The recently published study “Religious practices and quality of life in palliative care: insights from Tanzania” has brought to the forefront the indispensable role of spiritual practices in supporting patients with advanced cancer. The overwhelming demand for prayer and faith-based engagement demonstrates how religion provides meaning, resilience, and comfort in the face of terminal illness.