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Systematic Review Open Access

Autoimmune hepatic involvement in systemic sclerosis—systematic review and meta-analysis

  • 1Internal Medicine, Government Medical College, Amritsar, India
  • 2Internal Medicine, Henry Ford Allegiance Health, USA
  • 3Internal Medicine, Sri Manakula Vinayagar Medical College, India
  • 4Gastroenterology, Henry Ford Allegiance, Jackson, Michigan, USA
+ Affiliations - Affiliations

Corresponding Author

Bipneet Singh, drbipneetsingh18@gmail.com

Received Date: October 29, 2025

Accepted Date: December 23, 2025

Abstract

Systemic sclerosis (SSc) is a heterogeneous, multisystem autoimmune disease characterized by fibrosis in genetically predisposed individuals. It can involve multiple organ systems, but hepatic involvement is rare. 
In this study, we aim to find the correlation of liver disease, especially primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), in the population with SSc. Further, the correlation of anti-mitochondrial antibody (AMA) and other autoantibodies were done. 
Databases were searched for liver disease in SSc, and studies were selected for analysis. Cochrane risk of bias tools and meta-analysis online were used. Controls were taken from the prevalence in the respective countries around the same time.
There was a significant association between PBC and AIH, AMA positivity, and SSc. There was no association with liver fibrosis. 

Keywords

Primary biliary cholangitis, Autoimmune hepatitis, Systemic sclerosis, Anti-mitochondrial antibody

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