Abstract
Systemic sclerosis (SSc) is a heterogeneous, multisystem autoimmune disease characterized by fibrosis in genetically predisposed individuals. It can involve multiple organ systems, but hepatic involvement is rare.
In this study, we aim to find the correlation of liver disease, especially primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), in the population with SSc. Further, the correlation of anti-mitochondrial antibody (AMA) and other autoantibodies were done.
Databases were searched for liver disease in SSc, and studies were selected for analysis. Cochrane risk of bias tools and meta-analysis online were used. Controls were taken from the prevalence in the respective countries around the same time.
There was a significant association between PBC and AIH, AMA positivity, and SSc. There was no association with liver fibrosis.
Keywords
Primary biliary cholangitis, Autoimmune hepatitis, Systemic sclerosis, Anti-mitochondrial antibody