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Cell Signaling

ISSN: 2837-8253

Commentary Open Access
Volume 1 | Issue 1 | DOI: https://doi.org/10.46439/signaling.1.015

Development of an authentic light-activated calcium channel

Wenyu Li1, Liuqing Wang2, Youjun Wang 2,3, Lian He1,*
  • 1Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China
  • 2Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China
  • 3Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing, 100875, China
+ Affiliations - Affiliations

Corresponding Author

Lian He, hel3@sustech.edu.cn

Received Date: August 08, 2023

Accepted Date: October 07, 2023

Citation:

Li W, Wang L, Wang Y, He L. Development of an authentic lightactivated calcium channel. Cell Signal. 2023;1(1):72-75.


Copyright: © 2023 Li W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Optogenetic-based genetically encoded Ca2+ actuators (GECA) have been developed to enable remote control of Ca2+ entry into cells. However, current blue light-dependent tools either lack high calcium selectivity or exhibit crosstalk with other targets, raising concerns about potential side effects. In this commentary, we present our successful design of a single-component optogenetic Ca2+ ion channel (LOCa) that selectively elevates cytoplasmic Ca2+ concentration with high spatial and temporal resolution.
Furthermore, LOCa has demonstrated promising applications in regulating Ca2+-dependent cellular physiological responses and investigating diseases through animal models.

Keywords

Ca2+, Optogenetic, ORAI1, LOCa

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