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Commentary Open Access
Volume 4 | Issue 1 |

Disrupting oncogenic dialogue: An anti-TDE vaccine to block tumor progression and metastasis

  • 1Jiangzhong Cancer Research Center, JXUCM, Nanchang, Jiangxi, China 330004
  • 2Ocean Road Cancer Institute, P.O. Box 3592, Dar es Salaam, United Republic of Tanzania
+ Affiliations - Affiliations

Corresponding Author

Stephene S. Meena, stephen.meena@orci.or.tz
Ray P.S. Han, ray-han@jxutcm.edu.cn

Received Date: September 21, 2025

Accepted Date: October 23, 2025

Abstract

Tumor-derived exosomes (TDES) play a vital role in facilitating cancer development and dissemination through the trafficking of oncogenic nucleic acids and proteins, such as cytokines and chemokines, which remodel the tumor microenvironment (TME) to facilitate malignant traits. This process ultimately contributes to tumorigenesis, invasion, metastasis, and treatment resistance. Therefore, restricting cancer-induced communication with healthy cells by eliminating TDEs may serve as a promising approach to curb cancer progression and dissemination. In this commentary, we discuss the pivotal role of tumor-derived exosomes (TDEs) in cancer progression and metastasis, and propose a novel therapeutic strategy: an anti-TDE vaccine. Building on our preliminary work, which showed that pantoprazole can inhibit tumor cell proliferation by disrupting TDE secretion and altering the surface charge of secreted TDEs, we elaborate on a duplex approach to engineer tumors to produce 'tagged' TDEs that are both poorly absorbed and targeted for immune clearance. This novel approach can overcome most of the challenges of pharmacological inhibition, including off-target effects, wide diversity of biogenesis pathways, and drug delivery and specificity.

Keywords

Tumor-derived exosomes (TDEs), Oncogenic communication, Targeting TDEs, Anti-TDE vaccine

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