Available targeted therapies for colorectal cancer (CRC) are limited. Immunotherapy offers new options for cancer treatment, but most of CRC are refractory to current immune checkpoint blockade, which indicates the possible presence of yet uncharacterized immune-suppressive mechanisms. Herein we report that high levels of Dickkopf-related protein 2 (DKK2) are expressed in human CRC tumors, and the DKK2 blockade caused stronger activation of tumor-infiltrating CD8+ T cells in ex vivo culture. A correlation of high DKK2 expression 

Gastric or gastroesophageal junction (GEJ) adenocarcinoma remains a fatal condition worldwide, ranking fifth in prevalence and fourth in mortality globally [1]. The treatment of advanced gastric cancer is currently stratified based on MSI (Microsatellite Instability) status and HER2 status.

The formation of new blood vessels, or angiogenesis, is a hallmark of cancer and one of the most important conditions for tumor growth. Vascular endothelial growth factor (VEGF) is one of the most important factors in angiogenesis. Increased VEGF expression has been associated to rapid cancer progression and poor prognosis. 

Tetraspanins associate with many proteins and are involved in numerous activities like the crosstalk between cells and matrix, tumor progression, angiogenesis, and hematopoiesis. 

Brain tumors, especially malignant gliomas and metastases, continue to pose serious clinical challenges due to their complex biology and limited treatment options. The traditional research paradigm mainly focuses on the tumor cells themselves and their interaction with the immune microenvironment, while the critical role of the nervous system (including neurons, glial cells, neurotransmitters/modulators, and nerve fibers) in the pathological process of tumors has been underestimated for a long time.