We recently published an article describing the importance of CXCL17 in T cell responses [1]. In summary, we observed the following:
1) Cxcl17 is necessary to maintain normal ratios of T cell subpopulations in lymph nodes (LN).
2) Cxcl17-/- mice develop more intense inflammatory responses than wild type mice.

The significance of KIR like natural killer cell receptors in autoimmune disorders was published by us in the year 2020 in a reputed journal “Clinical Immunology”. In this issue we have discussed the complex nature of autoimmune diseases revealing a multi-factorial etiology that involves a combination of genetic and environmental factors

A reactor microbial sensor device and a membrane microbial sensor device are low-cost and convenient analytical tools, which are useful for assessment of constitutiveness and inducibility of enzyme systems for transport and initial metabolism of substrate in microbial cells.

Tau pathology in Alzheimer’s disease is known to hamper several cellular functions including  microtubule dynamics, proteostasis etc. Tau is a microtubule-stabilizing protein, playing an important role in maintaining the integrity of the axonal microtubules [1,2].

In a recent attempt to elucidate the role of HIF1α in modulating the fate of T cells, we have demonstrated that the targeted deletion of HIF1α, specifically in T cells, enhances the inflammatory capabilities and memory phenotype of CD8+ T cells. These findings validate that the T cell-specific ablation of HIF1α or pharmacological inhibition of HIF1α reduces the development of B16F10 melanomas, suggesting an improved anti-tumor immune response characterized by improved secretion of effector molecules, such as IFN-γ, granzyme B, and TNFα, in the CD8+ T cells. Thus, it appears that HIF1α might negatively influence specific effector functions of CD8+ T cells, which are crucial for destroying and targeting tumor cells.