Loading

Research Article Open Access
Volume 2 | Issue 2 | DOI: https://doi.org/10.46439/rheumatology.2.017

Galantamine has a positive impact on joint collagen degradation process in collagen-induced arthritis

  • 1Autoimmune Diseases Laboratory, Center for Experimental Research, Hospital de Clínicas de Porto Alegre. Ramiro Barcelos 2350. 90035-903 Porto Alegre / RS-Brazil
  • 2Graduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul. Ramiro Barcelos, 2400. 90035-003 Porto Alegre / RS-Brazil
  • 3Rheumatology service, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
  • #Authors made equal contributions to the study.
+ Affiliations - Affiliations

Corresponding Author

Ricardo Machado Xavier, rmaxavier@hcpa.edu.br

Received Date: November 03, 2021

Accepted Date: November 19, 2021

Abstract

Galantamine is an alkaloid extracted from plant bulbs of some members of the Amaryllidaceae family and is a reversible competitive inhibitor of acetylcholinesterase. GAL affects the cholinergic anti-inflammatory pathway. Since this effect indicates an immunomodulatory activity, we evaluated the efficacy of galantamine as an anti-inflammatory therapy in vivo in antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA). Mice were randomly divided into two groups: vehicle (treated with 0.9 % saline) and galantamine (GAL 4.4 mg/kg) with intraperitoneal administration. The AIA model was performed in Balb/C mice; nociception and leukocyte migration into the knee joint were evaluated after 24h of monoarthritis induction. The CIA was performed in DBA/1J mice with treatment starting after the disease onset with an 11 days duration. Evaluation of arthritis severity was made by clinical, histological scoring, body weight, edema, nociception, and collagen quantification. Our results showed that galantamine did not alter nociception and leucocyte articular migration in the AIA model and did not alter edema, nociception, clinical and histologic scoring in the CIA model. However, galantamine was able to maintain the collagen content in tibiotarsal joints of mice with CIA. In conclusion, galantamine may prevent collagen degradation in the joint by preserving both collagen content and the thickness of collagen fibers.

Keywords

Antigen-induced arthritis, Collagen-induced arthritis, Galantamine, Inflammation

Author Information X