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International Journal of Cardiology and Cardiovascular Diseases

ISSN: 2768-5640

Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/cardiology.3.023

Investigation of cardiac pacemaker channel HCN4 leads to new therapeutic approaches in the treatment of viral diseases associated with bradycardia/ cardiac arrest

Lena Mücher1, Nathalie Strutz-Seebohm1, Stefan Peischard1,#,*, Guiscard Seebohm1,#
  • #Contributes similarly to this study
  • 1Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149 Münster, Germany
+ Affiliations - Affiliations

Corresponding Author

Stefan Peischard, stefan.peischard@ukmuenster.de

Received Date: August 02, 2023

Accepted Date: August 14, 2023

Citation:

Mücher L, Strutz-Seebohm N, Peischard S, Seebohm G. Investigation of cardiac pacemaker channel HCN4 leads to new therapeutic approaches in the treatment of viral diseases associated with bradycardia/ cardiac arrest. Int J Cardiol Cardiovasc Dis. 2023;3(1):1-5.


Copyright: © 2023 Mücher L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Virus infections represent a serious threat for human health, causing immense costs and burdens for health systems. Viral diseases and their treatment are therefore of global interest, that extensively increased with the beginning of the SARS-CoV-2 pandemic at the end of 2019. About one third of myocarditis cases originate in infections caused by the enterovirus Coxsackievirus B3 (CVB3). The effects of CVB3 on the human pacemaker have been studied in detail. In human induced pluripotent stem cell derived pacemaker like cells, the pacemaker ion channel (HCN4) location has been found to be switched from membranous, to autophagosomal in a Rab7 dependant manner. Two CVB3 proteins have been of special interest, one being highly conserved in enteroviruses (CVB3 2C). Understanding of the CVB3 infection mechanism is therefore beneficial for the development of antiviral therapies and antiviral drugs. Additionally, the found mechanisms might potentially be transferable on other enteroviruses, providing therapy options for enteroviruses in general.

Keywords

Heart disease, Sinoatrial node, HCN4, Enterovirus, Coxsackievirus, Rab, GTPase

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Investigation of cardiac pacemaker channel HCN4 leads to new therapeutic approaches in the treatment of viral diseases associated with bradycardia/ cardiac arrest

Since the end of 2019, we have been in the midst of a global pandemic caused by the coronavirus SARS-CoV-2, which has caused immense costs for the global health system and has led to the death of many people. Since then, the number of publications dealing with viral diseases has risen sharply and the field of virology has become visible, partly because research into therapies and vaccinations against viral infections is now in the public spotlight.

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