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Commentary Open Access
Volume 2 | Issue 1 | DOI: https://doi.org/10.46439/signaling.2.042

The interplay of regulatory T cells, endoplasmic reticulum stress, and unfolded protein response activation in post-transplant alloimmune hepatitis and autoimmune hepatitis

  • 1Department of Surgery, Georgetown University School of Medicine, Washington, DC, USA
  • 2MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC, USA
+ Affiliations - Affiliations

Corresponding Author

 Udeme D. Ekong, Udeme.D.Ekong@gunet.georgetown.edu

Received Date: June 20, 2024

Accepted Date: August 02, 2024

Abstract

Autoimmune hepatitis and post-transplant alloimmune hepatitis are inflammatory conditions observed in the native and transplanted liver respectively. Regulatory T cells play a crucial role in the maintenance of immune tolerance and prevention of autoimmunity. Endoplasmic reticulum stress with unfolded protein response activation have been reported in circulating regulatory T cells suggesting a possible link between them. This review explores the role of regulatory T cells in autoimmunity focusing on their function and regulation in the liver. It also highlights the involvement of endoplasmic reticulum stress and unfolded protein response activation in autoimmune diseases. Understanding the interplay between endoplasmic reticulum stress, unfolded protein response activation and regulatory T cells may provide insights into disease pathogenesis and identify novel therapeutic targets for treatment of autoimmune liver diseases.

Keywords

Activating transcription factor 6 (ATF6), Regulatory T cell dysregulation, CCAAT/enhancerbinding protein homology protein (CHOP), Human endogenous retrovirus (HERV)

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