This editorial is a trial to open future research in the importance of neurobiology of diseases. We think that the potential of having links between some diseases and brain has been previously indicated, but it may be still underestimated.Previous studies reported the axis of brain and heart, brain and intestine. The reality of the problem is not well addressed on molecular basis. In other words, it is not enough to think or point out to possible existence of such a link. We need to develop some philosophical approaches to put theoretical frames. One of the previous studies showed that the exposure to brain traumatic injury through falling caused death after several days in ICU in hospital. It was surprising that the case of death was attributed to heart rather than traumatic brain injury. This was explained by increased expression of inducible nitric oxide synthase (iNOS) in cardiac tissue as a response to its over-expression in brain. It seems that brain can tolerate this high degree of iNOS expression, but heart cannot. This was thought to breakdown the molecular environment of the heart and led to death [1].  

We conducted further studies to confirm the following hypothesis: “Brain is a key with multiple links or channels through which brain functional changes impact other tissues, organs and systems”.

According to this hypothesis, the role of central nervous system including the brain exceeds controlling processes to pathologic initiation of diseases. We have demonstrated that diabetes, particularly type 1 to be linked with brain as well as pancreas through impacting the pancreas with shots of iNOS. We think again that pancreas functions can't tolerate the adverse effects of increased up-regulation of iNOS. We also reported that the involvement of white matter as a major site for iNOS targeting explains, even in part, the occurrence of such changes [2-7].

We also concluded that diabetic neuropathies and diabetes are independent events based on the same trend of understanding the role of nervous system [4].

We think that due to the phenomenon of neurogenesis, neurobiology may have other roles in initiation of cancer, but this needs more future works to be fully elucidated. We reached to this conclusion from examining cancer tissues in which we continuously used to see the involvement of nerve endings more than it is thought required for the tissue needs.

This hypothesis needs more studies to be well explored. In near future, we think that central nervous system including the brain may be therapeutically targeted to improve healing processes and to make new therapeutic strategies.