Archives of Clinical and Experimental Ophthalmology

Case Report Open Access

Neodymium:YAG laser posterior capsulotomy in the lateral decubitus position

J. Virdee, P. Mandal, A. Brown, I. Khan

Here we report a novel method of performing a Neodyminium:YAG (Nd:YAG) laser posterior capsulotomy in an adult patient, unable to tolerate the procedure awake with topical anaesthesia in the outpatient clinic setting. The procedure was performed by altering the chin rest and arms of the Nd:YAG laser machine so that the procedure could be undertaken in an anaesthetized patient in the operating theatre, in the lateral decubitus position, with the laser machine upright in its normal position.

Commentary Open Access

From observation to diagnosis: Implications of calcified sclero-choroidal choristomas in mosaic RASopathies

Brian M Grodecki, Saipriya C Potluri, Karl Olsen, Amgad Eldib, Hannah L Scanga, Matthew S Pihlblad, Ken K Nischal

The identification of calcified sclero-choroidal choristomas (CaSCCs) in patients with mosaic RASopathies introduces a new dimension to understanding ocular manifestations in these genetic disorders.

Commentary Open Access

How many mutations does it take to make a uveal melanoma?

Francesca Piaggio, Veronica Tozzo, Cinzia Bernardi, Michela Croce, Claudia Lo Sicco, Rosaria Gangemi, Roberto Puzone, Silvia Viaggi, Serena Patrone, Annalisa Barla, Domenico Coviello, Martine J. Jager, Pieter A. van der Velden, Davide Cangelosi, Alessandra Eva, Silvano Ferrini, Ulrich Pfeffer, Adriana Amaro

Uveal melanoma (UM) is a rare cancer that affects the choroid and, less frequently, the ciliary body or the iris (for recent reviews see [1-3]). Despite a profound knowledge of the oncogenic mechanisms behind UM tumorigenesis and despite an accurate cytogenetic and molecular prognosis, only limited advances have been made in UM therapy.

Research Article Open Access

Involvement of TGFβ signaling pathway in oxidative stress and diabetic retinopathy

Reanna Rodriguez, Kristine Lowe, Megan Keniry, Andrew Tsin

Diabetic Retinopathy (DR) is a leading cause of blindness in the U.S. However, not much is known of underlying molecular mechanism and how oxidative stress contributes to its development. In the present study, we investigated the involvement of TGFβ signaling pathway on the effect of oxidative stress on VEGF secretion and viability of retinal cells. VEGF is the hallmark that exacerbates DR progression in prolonged diabetes. Some major concerns that have arisen are the underlying effects of antioxidants in elevating VEGF secretion in diabetes.

Short Communication Open Access

Recent advances on visual cycle protein research and progress on clinical translation

Xin Yee Ooi, Rujman Khan, Anjalee Choudhury, Francisco Xavier Elisarraras, Jeff Grigsby, Brandi Obregon, Andrew Tsin

Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP.