Archives of Clinical and Experimental Ophthalmology

Commentary Open Access

From observation to diagnosis: Implications of calcified sclero-choroidal choristomas in mosaic RASopathies

Brian M Grodecki, Saipriya C Potluri, Karl Olsen, Amgad Eldib, Hannah L Scanga, Matthew S Pihlblad, Ken K Nischal

The identification of calcified sclero-choroidal choristomas (CaSCCs) in patients with mosaic RASopathies introduces a new dimension to understanding ocular manifestations in these genetic disorders.

Letter to the Editor Open Access

Presbyopia correcting IOLs and the ocular surface disease… The good, the bad and the ugly

Slavomir Kirilov

The last two decades were especially fruitful for the refractive surgeons and for the industry who have been showing tremendous development in both understanding and meeting patients’ desire for spectacle independence. Ever since the first trials from Dr. Kenneth Hoffer with his early 1980’s effort in producing a multifocal IOL to the latest achievements from different companies in putting trifocals and EDOF optics to the market.

Commentary Open Access

How many mutations does it take to make a uveal melanoma?

Francesca Piaggio, Veronica Tozzo, Cinzia Bernardi, Michela Croce, Claudia Lo Sicco, Rosaria Gangemi, Roberto Puzone, Silvia Viaggi, Serena Patrone, Annalisa Barla, Domenico Coviello, Martine J. Jager, Pieter A. van der Velden, Davide Cangelosi, Alessandra Eva, Silvano Ferrini, Ulrich Pfeffer, Adriana Amaro

Uveal melanoma (UM) is a rare cancer that affects the choroid and, less frequently, the ciliary body or the iris (for recent reviews see [1-3]). Despite a profound knowledge of the oncogenic mechanisms behind UM tumorigenesis and despite an accurate cytogenetic and molecular prognosis, only limited advances have been made in UM therapy.

Short Communication Open Access

MSICS is a Simple Solution for a Big Problem

Mohamed. A. Almousa

Manual small-incision cataract surgery (MSICS) is a sutureless cataract surgery that has multiple advantages over traditional phacoemulsification and extracapsular cataract extraction (ECCE) procedures. SICS became the procedure of choice for international ophthalmology, where the microscopes and operating room can be more challenging, in addition to the more advanced pathology often seen.

Short Communication Open Access

Recent advances on visual cycle protein research and progress on clinical translation

Xin Yee Ooi, Rujman Khan, Anjalee Choudhury, Francisco Xavier Elisarraras, Jeff Grigsby, Brandi Obregon, Andrew Tsin

Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP.