Diabetes is a complex, multi-symptomatic disease whose complications drives increases in healthcare costs as the diabetes prevalence grows rapidly world-wide. Real-world electronic health records (EHRs) coupled with patient biospecimens, biological understanding, and technologies can characterize emerging diagnostic autoimmune markers resulting from proteomic discoveries.

Gastric marginal zone lymphoma (gMZBL) is the most frequent type of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). The histology of gMZBL shows typical small cell morphology, however, there also exists a large cell variant.

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal Non Hodgkin Lymphoma. Combined modality treatment with high-dose methotrexate (HD-MTX) followed by whole brain radiotherapy (WBRT) has been a commonly used treatment approach.

Intravascular large B-cell lymphoma (IVLBCL) is a rare and specific variant of diffuse large B-cell lymphoma (DLBCL). Epstein-Barr virus (EBV)-positive IVLBCL is particularly rare and highly aggressive. Up to present, only a few cases of EBV-positive IVLBCL have been reported in the literature. Here, we would like to further explore its clinicopathological and molecular features to ensure the awareness and accurate diagnosis of this entity.

Sézary's Syndrome consists of a rare type of non-Hodgkin cutaneous T-cell lymphoma (CTCL), being a very aggressive leukemic variant of CTCL. Given its rarity and its ability to mimic other more common diseases, this neoplasm represents a major diagnostic challenge for both clinicians and pathologists.