Journal of Clinical and Experimental Gastroenterology

Enteric duplication cysts are rare congenital malformations of the gastrointestinal tract that can be found anywhere along the entire alimentary canal. Duplication cysts share a muscular layer with the adjacent bowel and contain their own mucosal lining which may be that of any part of the alimentary tract. 

Transient receptor potential (TRP) family is a large superfamily of widely expressed ion channels. In recent years, several studies have been conducted on the mechanism of action of TRP. However, studies on the role of TRP in liver diseases are limited. In fact, TRP plays a vital role in the progression of many liver diseases, such as hepatic fibrosis, hepatocellular carcinoma, alcoholic fatty liver disease, and nonalcoholic fatty liver disease.

Spontaneous scrotal enterocutaneous fistulas (ECFs) are rare. They are more common in countries with poor access to medical care. Based on our literature search, our patients represent the first two reported adult cases of scrotal ECFs in the United States. 

Gastric marginal zone lymphoma (gMZBL) is the most frequent type of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). The histology of gMZBL shows typical small cell morphology, however, there also exists a large cell variant.

Ischemic colitis (IC) is a common cause of severe lower gastrointestinal bleeding (LGIB) in the elderly. There are very few studies of patients with IC as a cause of severe LGIB in the literature. This article aims to review diagnosis, colonoscopic findings, medical treatment, and outcomes of patients with IC as a cause of severe hematochezia.

Tuberculosis of the appendix is a rare finding despite the high frequency of intestinal tuberculosis. Even in areas where tuberculosis is common, it is difficult to make the right diagnosis because of the clinical picture mimicking acute appendicitis, when there are no definitive signs of any system infected with tuberculosis [1].

Gastrointestinal stromal tumors are mesenchymal tumors which predominantly originate from the interstitial cells of Cajal in the intestinal lining. Around ~85% of malignant GISTs possess activating mutations in the tyrosine kinase receptors KIT or PDGFRA. The driver mutations in genes other than KIT or PDGFRA account for around 15% GISTs and belong to highly heterogeneous groups called wild-type GISTs. Around 20–40% of WT-GISTS are deficient for the succinate dehydrogenase complex (SDHA, SDHB, SDHC, SDHD). 

The superior mesenteric artery syndrome is an uncommon entity included in the spectrum of vascular syndromes. The low presentation, variety of unspecific symptoms, and shortage of bibliography presents a challenging diagnosis for both clinicians and radiologists. Our aim is to present a 63 years-old male patient with pancreatitis history and repeated symptoms. 

A series of studies suggested that hypertension is significantly associated with the risk of gallstone disease (GSD). However, due to differences in study design, population stratification, sample size, and diagnostic criteria for GSD, the results of each study are inconsistent, limiting the strength and application of these pieces of evidence. 

Objective: This manuscript is a mini review of the outpatient management of non-complicated acute appendicitis. We reviewed the literature supporting the safety and efficacy of outpatient management of laparoscopic appendectomy in adult patients with uncomplicated acute appendicitis.

Background: Pain is a very important factor in patient recovery and satisfaction. Following incision and drainage of perianal abscess, wound packing has been found to be very painful. The aim of this study is to compare packing the wound and not packing the wound after incision and drainage (I&D) of perianal abscess, taking into account recurrence rate, rate of occurrence of perianal fistula as well as post-operative pain. 

Background and Aim: Non-Alcoholic Fatty Liver Disease (NAFLD) is the commonest cause of chronic liver disease and is a leading cause of liver transplantation in the United States, with no approved medication to halt or reverse its progression. Recent animal-model prospective trial-suggested that drug Vedolizumab leads to improvement and reversal in the NAFLD-related metabolic derangements. Vedolizumab is an α4β7 integrin-inhibitor that is approved for use in IBD patients. Our study aims to understand Vedolizumab's impact on the course of NAFLD in inflammatory bowel disease (IBD) patients.

Pediatric Functional Gastrointestinal Disorders (p-FGID) comprise one of the most common chronic conditions impacting global health. Conceptualized as gut-brain communication disorders, p-FGID are often exacerbated by and contribute to significant anxiety as well as functional impairment. Cognitive behavioral therapy is the gold standard psychosocial treatment for anxiety spectrum disorders. 

Primary gastric mucormycosis is a rare but potentially lethal fungal infection due to the invasion of Mucorales into the gastric mucosa. It may result in high mortality due to increased risk of complications in immunocompromised patients. Common predisposing risk factors to develop gastric mucormycosis are prolonged uncontrolled diabetes mellitus, solid organ, or stem cell transplantation, underlying hematologic malignancy, and major trauma. 

Olmesartan drug-induced enteropathy was first reported 10 years ago. Its physiopathology remains largely unknown and its evocation facing diarrhea is still not systematic, especially in cases of acute and severe diarrhea episodes. In this paper, we report the case of a 71-year-old woman presenting with acute diarrhea associated with complete duodenal mucosal villous atrophy with lymphocytic infiltration.

A 30-year-old woman presented with 6-month history of blood-stained stools. The patient denied a family history of colon cancer. Examination was remarkable for blood-streaked stool.

Introduction: Peptic ulcer disease (PUD) is the most common disease of the stomach and duodenum, which affects daily life and is associated with Helicobacter pylori and drug-induced problems. PHD occurs due to increased aggressive factors (like HCl, gastrin, pepsin, etc.) and decreased protective factors (like mucosa secretion, and prostaglandin activity). According to recent research, up to 10% of the global population suffers with PUD. 

Background: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is a well-established diagnostic tool to obtain tissue from solid pancreatic masses, gastrointestinal subepithelial lesions, lymph nodes, liver as well as other neighboring organs. EUS-TA has proven to have a major clinical impact in diagnosis and staging, decreasing the need for invasive diagnostic procedures, such as thoracoscopy, mediastinoscopy, laparoscopy and open surgery.

Histopathology, defined as study of diseased cells and tissues is the science dealing with the study of biopsies and tissues under the microscope to form a possible diagnosis based on the morphology of the cells and surrounding tissues [1].

Background: There were well-known racial/ethnic differences in colorectal cancer (CRC) screening in the United States (US). 
Aims: To study the rate of CRC screening recommendation for individuals not up-to-date on screening and whether there were racial/ethnic differences in recommendation. 
Data and Methods: All adults 50 to 75 years old in the 2021 National Health Interview Survey who were not up-to-date on CRC screening were included. The rate of CRC screening recommendation in the past 12 months was calculated for non-Hispanic Whites, Blacks/African Americans, Hispanics, and Asians respectively. Multivariate logistic regression was used to examine racial/ethnic differences in CRC screening recommendation, controlling for demographic and socioeconomic variables (age, sex, immigrant, college education and insured).