Journal of Clinical and Experimental Gastroenterology

The recent pandemic of SARS-CoV-2 has emerged as a health emergency to develop effective therapeutic strategies for restricting deadly disease, COVID-19. SARS-CoV-2 infects cells by the endocytosis process via receptor-mediated binding and priming by cellular proteases.

Arthritis remains a common and debilitating disease affecting millions of people worldwide. Osteoarthritis (OA) and rheumatoid arthritis (RA) are among the most common forms of this chronic, degenerative disease, which is moving toward precision medicine.

The lotus or Indian lotus has a rich history of traditional use in various cultures for its medicinal properties [1,2], with the increasing prevalence of diseases such as cancer, diabetes, and inflammatory conditions, there is a growing interest in exploring natural products for their therapeutic potential [3-6].

The mechanistic target of rapamycin (mTOR), a critical regulator of cell growth, metabolism, survival, and actin-cytoskeletal organization, is primarily recognized for its cytoplasmic functions. However, emerging evidence suggests that the mTOR and its constituent partners also localize to the nucleus, where it may play distinct roles in gene expression regulation, chromatin remodeling, and transcriptional control. This review highlights the evolving understanding of nmTORC2 (nuclear mTORC2), with a particular focus on its composition, functional implications, and relevance in cancer biology.

Gastrointestinal (GI) angiodysplasia represents one of the most vexing diagnostic and therapeutic challenges in clinical gastroenterology. These arteriovenous malformations, predominantly affecting the cecum, right colon, and small bowel, are the most common vascular lesions of the GI tract and account for a disproportionately large share of obscure GI bleeding, particularly in elderly patients.