This editorial is a trial to open future research in the importance of neurobiology of diseases. We think that the potential of having links between some diseases and brain has been previously indicated, but it may be still underestimated.Previous studies reported the axis of brain and heart, brain and intestine. The reality of the problem is not well addressed on molecular basis. In other words, it is not enough to think or point out to possible existence of such a link.

During an action observation (AO) and action execution, specific group of neural substrates are activated. They provide a neural mechanism for understanding the actions of others called as mirror neurons (MNs). They also carry out motor grounding, motion ersatz, language and emotion appreciation. Mirror neurons discharge not only throughout the self-experience of pain but also during the perception of other people’s pain.

Different computational models and new devices are under development, aiming to better comprehend and alter brain function. Ternary computating offers new approach by considering a third physiological state of the neuronal membrane: the refractory period (-1), in addition to resting potential state (0) and the action potential.

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal Non Hodgkin Lymphoma. Combined modality treatment with high-dose methotrexate (HD-MTX) followed by whole brain radiotherapy (WBRT) has been a commonly used treatment approach.

The human brain is a complex network of billions of neurons accompanied by astrocytes and microglia among others [1]. Neurons communicate via specialized sites of cell-cell contacts called synapses, where information is transmitted via the presynaptic release of neurotransmitter from synaptic vesicles (SVs) [2]. Through the integration of information transmitted via large networks of neurons, complex tasks, such as learning, memory and various behaviors, are regulated.